Oral Diabetes Meds
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each of the black spaces below before clicking
on it to display the answer.
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| Biguanide: Metformin Actions | Drug of choice for type 2 DM. Decreases glucose production by the liver, increases tissue response to insulin.
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| Biguanide: Metformin Adverse Effects | GI symptoms: decreased apetite, nausea, diarrhea. Lactic acidosis (rarely) Little risk for hypogycemia.
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| Sulfonylureas: Tobutamide, Glipizide, Glyburide Actions | Promote insulin secretion by the pancreas
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| Sulfonylureas: Tobutamide, Glipizide, Glyburide Adverse Effects | Hypoglycemia
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| Thiazolidinediones: Rosiglitazone, Pioglitazone Actions | Decrease insulin resistance and thereby increase glucose uptake by muscle and decrease glucose production by the liver. Adverse effect: hypogylcemia in the presence of excess insulin.
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| Alpha-glucosidase Inhibitors: Acarbose, Miglitol | Inhibit carbohydrate digestion and absorption thereby decreasing the posprandial rise in blood glucose. GI symptoms; flatulence, cramps, abdominal distention, borborygmus
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| Gliptins: Sitagliptin | Enhances the activity of incretins and thereby increases insulin release, reduces glucagon release, and decrease glucose production. No adverse effects identified yet.
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