Digoxin
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| Class | Cardiac glycoside
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| MOA | Inhibits Na+ K+ pump=increaed Na and Ca in the intracellular space=increased cardiac contractility (+inotropic effect)
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| MOA | decreases vagal tone=decreased SA node firing,prolongs conduction through AV=(-chronotropic)
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| MOA | In a-fib and A-flutter it decreases the number of atrial impulses(-chronotropic)
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| MOA | improves CO (decreases baroreceptor response=decreased SNS discharging=decreased BP due to (+inotropic effects)
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| Indications | Controls ventricular rate in A-fib/A-flutter
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| Indications | psvt
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| Indication | CHF
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| Indication | Cardiogenic Shock
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| Contra | V-vib/V-tach
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| Contra | 2nd and 3rd heart block- in the absence of a parcemaker
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| Contra | Digitalis toxicity
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| Supplied | 0.25 mg-1mg in 1-2 ml SIVP
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| Initial dose | 4-6 mcg/kg over 5 min SIVP
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| 2nd and 3rd doses | 2-3 mcg/kg
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| CNS side effects | Anorexia,confusion,delerium,headache,cns depression,weak
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| Cardi SE | a-fib-LT,V-fib/V-tach-LT,AV block-LT, brady,hypo
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| Blood SE | thrombocytopenia
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| GI SE | diarreah,hemmoraggic necrosis of the intestine,n/v
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