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Drugs

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
show 1) Help the liver to produce less glucose, 2) help the pancreas to release more insulin, 3) may stimulate Beta cells to produce insulin to: increase receptor sites on cell membrane, increase receptor site sensitivity  
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3 types of OADs & functions:   show
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Old Class I   show
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show Amaryl (Glimepiride), Diabeta, Glynase, Micronase (Glyburide), Glucotrol, Glucotrol XL (Glipizide), Diabinese (Chlorpropamide)  
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Sulfonylureas (important facts)   show
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Sulfonylureas (side effects, drug interactions)   show
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Newer Class 1 Meglitinides 2 brand/generic   show
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Meglitinides (important facts)   show
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Meglitinides (more facts)   show
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show Biguanides  
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Class 2 Biguanides 1 brand/generic   show
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show Metformin keeps liver from releasing too much glucose, is active in the liver; makes liver more sensitive - so blocks glucose from being produce in liver, pos effect on CHO, insulin sensitizers, no wt gain (lose 5-10), decrease risk of hypoglycemia  
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Side effects of Glucophage/Metaformin:   show
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Risk factors for Lactic acidosis:   show
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Class 2: Insulin sensitizers   show
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show Avandia (Rosilitazone), Actos (Pioglitazone)  
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show These drugs improve insulin sensitivity, aiding cells to use BG for energy, low risk of hypoglycemia, wt gain/peri edema, take 12 wks to see effect, very expensive but effective, monitor liver function  
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show Alpha-Glucosidase Inhibitors  
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show Precose (Acarbose), Glyset (Miglitol)  
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Alpha-Glucosidase Inhibitors facts:   show
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Alpha-Glucosidose Inhibitors con'd:   show
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Drugs which cause hyperglycemia:   show
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