1. How many half lives does it take to get to steady state?
2. What percentage of steady state is reached after one half-life?
1. 4-5 half lives
2. 50%
1. What role do beer, red wine and cheese play in drug metabolism?
2. zero-order elimination
3. first order elimination
1. contain tyramine that is metabolized by phase I monoamine oxidase reaction
2. constant amount eliminated
3. constant fraction eliminated
Inhibitors of cytochrome P450:
Inhibit drinking from a KEG or you'll be Acutely SICk
1. Ketoconazole
2. Erythromycin
3. Grapefruit juice
4. Acute alcohol
5. Sulfonamides
6. Isoniazide
7. Cimetidine
Which kind of antagonism:
1. competitive antagonism for the same receptor
2. two agonist with opposing action (i.e. vasoconstrictor vs vasodilator)
3. interacts directly with drug to remove it or prevent it from binding target
1. Pharmacologic antagonist
2. Physiologic antagonism
3. Chemical antagonism
At what pH would the following drugs be ionized?
1. acidic drugs
2. basic drugs
1. high pH (drug donates a proton to environment)
2. low pH (drug accepts a proton from environment)
1. Methylene blue
2. Ethanol
3. Naloxone/naltrexone
4. Flumazenil
1. Where is the cell are cytochrome P450 enzymes found?
2. Which cytochrome P450 enzyme metabolizes a majority of the drugs on the market?
3. Which drugs induce SLE-like symptoms?
