Question | Answer |
MOA of sulfonamides | PABA analogue that inhibits microbial dihydropteroate synthase, preventing folic acid synthesis |
You can’t use Dapsone in a Pt with | G6PD deficiency |
PABA analogue used in susceptible vaginal infections | sulfanilamide |
PABA analogue used against Toxoplasmosis | sulfadiazine |
What to avoid using with sulfonamides | Sunscreen AKA PABA |
6 serious side effects of sulfonamides | kernicterus in newborns, crystaluria, SJ syndrome, agranulocytosis, aplastic anemia, hepatic failure |
PABA analogue used with Leprosy and dermatitis herpetiformis | dapsone |
7 serious SE of dapsone | Hemolytic anemia, methemoglobinemia, TEN, erythema nodosum, pancreatitis, toxic hepatitis, peripheral neuropathy |
Selectively inhibits bacterial DHFR | trimethoprim |
Selectively inhibits parasitic DHFR | pyrimethamine |
2 drugs used together to treat toxoplasmosis | sulfadiazine/pyrimethamine |
3 serious SE of trimethoprim and pyrimethamine | SJ syndrome, leukopenia, megaloblastic anemia |
Selectively inhibits mammalian DHFR | methotrexate |