| Question | Answer |
| Actinomycin | -Intercalates into DNA and blocks RNA and DNA synthesis
-IV
-Bone marrow depression, radiation recall |
| Anastrazole | -CYP19 aromatase inhibitor
-Oral
-Toxicity related to estrogen deficiency |
| (L)Aspariginase | -Degrades asparagine in the circulation and starves tumor cells for this amino acid
-IV
-Hypersensitivity reactions |
| Bevacizumab | -Antibody against VEGF
-IV
-Hypertension, GI perforation |
| Bleomycin | -Interacts with DNA and catalyzes free radical formation and DNA destruction
-IV, IM
-Pulmonary fibrosis, skin changes, radiation recall |
| Cisplatin | -Cross-linking DNA
-IV
-Bone marrow depression, renal tubuar damage |
| Cyclophosphamide | -Alkylation and cross-linking DNA
-IV, Oral
-Bone marrow depression, male sterility, amenorrhea |
| Cytosine arabinoside | -Inhibits DNA polymerase, mis-incorporates into DNA
-IV
-Bone marrow depression |
| Doxorubicin | -Inhibit Topoisomerase II/DNA complex
-IV
-Bone marrow depression, cardiomyopathy, radiation recall |
| Etoposide | -Inhibits Topoisomerase II/DNA complex
-Oral, IV
-Bone marrow depression |
| 5-florouracil | -Inhibits thymidylate synthetase, misincorporation into DNA
-IV
-Bone marrow depression |
| Gefitnib | -EGF receptor inhibitor
-Oral
-Skin problems |
| Hydroxyurea | -Inhibits ribonucleotide reductase
-Oral
-Bone marrow depression |
| Imatinib | -Inhibits ABL tyrosine kinase
-Oral
-Fluid retention |
| Irinotecan | -Inhibits Topoisomerase I/DNA complex
-IV, Oral
-Bone marrow depression |
| Leuprolide | -GnRH analog that causes GnRH receptor down regulation
-SubQ
-Hormone withdrawal effects |
| Mechlorethamine | -Alkylation & cross-linking DNA
-IV, intracavitary
-Bone marrow depression, male sterility, amenorrhea |
| Methotrexate | -DHF reductase inhibitor
-IV, Oral, intrathecal
-Bone marrow depression |
| Paclitaxel (Taxol) | -Binds tubulin, stabilizes microtubules
-IV
-Bone marrow depression, sensory neuropathy |
| Tamoxifen | -Estrogen receptor binder
-Oral
-Hot flashes, risk increase for endometrial cancer, thromboembolic events |
| 6-Thioguanine | -Inhibits purine biosynthesis
-Oral
-Bone marrow depression |
| Trastuzumab (Herceptin) | -Binds Her2 on cancer cells and stimulates antibody-dependent cellular cytotoxicity
-IV
-Cardiotoxic |
| Vinblastine | -Grabs tubulin, prevents microtubule polymerization
-IV
-Bone marrow depression, mild peripheral neuropathy |
| Vincristine | -Grabs tubulin, prevents microtubule polymerization
-IV
-Peripheral neuropathy |
| Allupurinol | -Inhibits xanthine oxidase to prevent uric acid buildup after cell death due to cytotoxic drugs
-Oral
-Sensitivity reactions |
| Leucovorin | -5-formyl-THF, rescues methotrexate toxicity
-IM, IV, Oral |
| Filgastim (G-CSF) | -Hematopoetic agent, stimulates neutrophil production
-IV, SubQ
-Mild to moderate bone pain, skin reactions |
