Question | Answer |
Actinomycin | -Intercalates into DNA and blocks RNA and DNA synthesis
-IV
-Bone marrow depression, radiation recall |
Anastrazole | -CYP19 aromatase inhibitor
-Oral
-Toxicity related to estrogen deficiency |
(L)Aspariginase | -Degrades asparagine in the circulation and starves tumor cells for this amino acid
-IV
-Hypersensitivity reactions |
Bevacizumab | -Antibody against VEGF
-IV
-Hypertension, GI perforation |
Bleomycin | -Interacts with DNA and catalyzes free radical formation and DNA destruction
-IV, IM
-Pulmonary fibrosis, skin changes, radiation recall |
Cisplatin | -Cross-linking DNA
-IV
-Bone marrow depression, renal tubuar damage |
Cyclophosphamide | -Alkylation and cross-linking DNA
-IV, Oral
-Bone marrow depression, male sterility, amenorrhea |
Cytosine arabinoside | -Inhibits DNA polymerase, mis-incorporates into DNA
-IV
-Bone marrow depression |
Doxorubicin | -Inhibit Topoisomerase II/DNA complex
-IV
-Bone marrow depression, cardiomyopathy, radiation recall |
Etoposide | -Inhibits Topoisomerase II/DNA complex
-Oral, IV
-Bone marrow depression |
5-florouracil | -Inhibits thymidylate synthetase, misincorporation into DNA
-IV
-Bone marrow depression |
Gefitnib | -EGF receptor inhibitor
-Oral
-Skin problems |
Hydroxyurea | -Inhibits ribonucleotide reductase
-Oral
-Bone marrow depression |
Imatinib | -Inhibits ABL tyrosine kinase
-Oral
-Fluid retention |
Irinotecan | -Inhibits Topoisomerase I/DNA complex
-IV, Oral
-Bone marrow depression |
Leuprolide | -GnRH analog that causes GnRH receptor down regulation
-SubQ
-Hormone withdrawal effects |
Mechlorethamine | -Alkylation & cross-linking DNA
-IV, intracavitary
-Bone marrow depression, male sterility, amenorrhea |
Methotrexate | -DHF reductase inhibitor
-IV, Oral, intrathecal
-Bone marrow depression |
Paclitaxel (Taxol) | -Binds tubulin, stabilizes microtubules
-IV
-Bone marrow depression, sensory neuropathy |
Tamoxifen | -Estrogen receptor binder
-Oral
-Hot flashes, risk increase for endometrial cancer, thromboembolic events |
6-Thioguanine | -Inhibits purine biosynthesis
-Oral
-Bone marrow depression |
Trastuzumab (Herceptin) | -Binds Her2 on cancer cells and stimulates antibody-dependent cellular cytotoxicity
-IV
-Cardiotoxic |
Vinblastine | -Grabs tubulin, prevents microtubule polymerization
-IV
-Bone marrow depression, mild peripheral neuropathy |
Vincristine | -Grabs tubulin, prevents microtubule polymerization
-IV
-Peripheral neuropathy |
Allupurinol | -Inhibits xanthine oxidase to prevent uric acid buildup after cell death due to cytotoxic drugs
-Oral
-Sensitivity reactions |
Leucovorin | -5-formyl-THF, rescues methotrexate toxicity
-IM, IV, Oral |
Filgastim (G-CSF) | -Hematopoetic agent, stimulates neutrophil production
-IV, SubQ
-Mild to moderate bone pain, skin reactions |