| Question | Answer |
| Methamphetamine/Amphetamine | Stimulant /
Stimulates the release of monoamines in a non-vesicular manner. Displaces monoamines from vesicles thus forcing uptake protein to dump. |
| Cocaine | Stimulant /
Decreases the uptake of monoamines thus increasing levels in the synaptic cleft. Inhibits NET, DAT, SAT |
| Nicotine | Stimulant /
Stimulates reticular activating system and DA release into nucleus accumbens and prefrontal cortex. |
| Morphine | Opoids (Depressants) /
Activation of opioid receptors (Gi, G protein) to decrease presynaptic calcium channel opening and increase postsynaptic potassium channel opening. Also decreases activation of GABA and thus disinhibits dopamine to NA. |
| Heroin | Opoids (Depressants) /
Activation of opioid receptors (Gi, G protein) to decrease presynaptic calcium channel opening and increase postsynaptic potassium channel opening. Also decreases activation of GABA and thus disinhibits dopamine to NA. |
| Coedine | Opoids (Depressants) /
Activation of opioid receptors (Gi, G protein) to decrease presynaptic calcium channel opening and increase postsynaptic potassium channel opening. Also decreases activation of GABA and thus disinhibits dopamine to NA. |
| Oxycodone | Opoids (Depressants) /
Activation of opioid receptors (Gi, G protein) to decrease presynaptic calcium channel opening and increase postsynaptic potassium channel opening. Also decreases activation of GABA and thus disinhibits dopamine to NA. |
| Fentanyl | Opoids (Depressants) /
Activation of opioid receptors (Gi, G protein) to decrease presynaptic calcium channel opening and increase postsynaptic potassium channel opening. Also decreases activation of GABA and thus disinhibits dopamine to NA. |
| Alprazolam | Benzodiazepines (Depressants) /
Positive allosteric modulator at GABA-a receptors acting to enhance the frequency of channel opening in response to GABA. Enhanced sensory perceptions, feeling of social closeness, amnesia. |
| Diazepam | Benzodiazepines (Depressants) /
Positive allosteric modulator at GABA-a receptors acting to enhance the frequency of channel opening in response to GABA. Enhanced sensory perceptions, feeling of social closeness, amnesia. |
| Lorazepam | Benzodiazepines (Depressants) /
Positive allosteric modulator at GABA-a receptors acting to enhance the frequency of channel opening in response to GABA. Enhanced sensory perceptions, feeling of social closeness, amnesia. |
| GHB (Gamma-hydroxybutyric acid) | Depressant /
Agonist at GABA-B receptors /
Euphoria, enhanced sensory perceptions, feeling of social closeness, amnesia. |
| Alcohol | Depressant /
Many actions including GABA-A allosteric modulator. |
| LSD | Hallucinogens /
5-HT2A receptors in prefrontal cortex |
| PCP | Hallucinogens /
Block NBMA glutamate receptor |
| Ketamine | Hallucinogens /
Block NBMA glutamate receptor |
| Marijuana | Cannabinoids /
Bind CB1 receptor in brain to inhibit release of glutamate or GABA |
| THC | Cannabinoids /
Bind CB1 receptor in brain to inhibit release of glutamate or GABA |
| K2/Spice | Cannabinoids /
Bind CB1 receptor in brain to inhibit release of glutamate or GABA |
