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Drugs of Abuse
All drugs that are abused
| Question | Answer |
|---|---|
| Methamphetamine/Amphetamine | Stimulant / Stimulates the release of monoamines in a non-vesicular manner. Displaces monoamines from vesicles thus forcing uptake protein to dump. |
| Cocaine | Stimulant / Decreases the uptake of monoamines thus increasing levels in the synaptic cleft. Inhibits NET, DAT, SAT |
| Nicotine | Stimulant / Stimulates reticular activating system and DA release into nucleus accumbens and prefrontal cortex. |
| Morphine | Opoids (Depressants) / Activation of opioid receptors (Gi, G protein) to decrease presynaptic calcium channel opening and increase postsynaptic potassium channel opening. Also decreases activation of GABA and thus disinhibits dopamine to NA. |
| Heroin | Opoids (Depressants) / Activation of opioid receptors (Gi, G protein) to decrease presynaptic calcium channel opening and increase postsynaptic potassium channel opening. Also decreases activation of GABA and thus disinhibits dopamine to NA. |
| Coedine | Opoids (Depressants) / Activation of opioid receptors (Gi, G protein) to decrease presynaptic calcium channel opening and increase postsynaptic potassium channel opening. Also decreases activation of GABA and thus disinhibits dopamine to NA. |
| Oxycodone | Opoids (Depressants) / Activation of opioid receptors (Gi, G protein) to decrease presynaptic calcium channel opening and increase postsynaptic potassium channel opening. Also decreases activation of GABA and thus disinhibits dopamine to NA. |
| Fentanyl | Opoids (Depressants) / Activation of opioid receptors (Gi, G protein) to decrease presynaptic calcium channel opening and increase postsynaptic potassium channel opening. Also decreases activation of GABA and thus disinhibits dopamine to NA. |
| Alprazolam | Benzodiazepines (Depressants) / Positive allosteric modulator at GABA-a receptors acting to enhance the frequency of channel opening in response to GABA. Enhanced sensory perceptions, feeling of social closeness, amnesia. |
| Diazepam | Benzodiazepines (Depressants) / Positive allosteric modulator at GABA-a receptors acting to enhance the frequency of channel opening in response to GABA. Enhanced sensory perceptions, feeling of social closeness, amnesia. |
| Lorazepam | Benzodiazepines (Depressants) / Positive allosteric modulator at GABA-a receptors acting to enhance the frequency of channel opening in response to GABA. Enhanced sensory perceptions, feeling of social closeness, amnesia. |
| GHB (Gamma-hydroxybutyric acid) | Depressant / Agonist at GABA-B receptors / Euphoria, enhanced sensory perceptions, feeling of social closeness, amnesia. |
| Alcohol | Depressant / Many actions including GABA-A allosteric modulator. |
| LSD | Hallucinogens / 5-HT2A receptors in prefrontal cortex |
| PCP | Hallucinogens / Block NBMA glutamate receptor |
| Ketamine | Hallucinogens / Block NBMA glutamate receptor |
| Marijuana | Cannabinoids / Bind CB1 receptor in brain to inhibit release of glutamate or GABA |
| THC | Cannabinoids / Bind CB1 receptor in brain to inhibit release of glutamate or GABA |
| K2/Spice | Cannabinoids / Bind CB1 receptor in brain to inhibit release of glutamate or GABA |