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Drugs of Abuse

All drugs that are abused

QuestionAnswer
Methamphetamine/Amphetamine Stimulant / Stimulates the release of monoamines in a non-vesicular manner. Displaces monoamines from vesicles thus forcing uptake protein to dump.
Cocaine Stimulant / Decreases the uptake of monoamines thus increasing levels in the synaptic cleft. Inhibits NET, DAT, SAT
Nicotine Stimulant / Stimulates reticular activating system and DA release into nucleus accumbens and prefrontal cortex.
Morphine Opoids (Depressants) / Activation of opioid receptors (Gi, G protein) to decrease presynaptic calcium channel opening and increase postsynaptic potassium channel opening. Also decreases activation of GABA and thus disinhibits dopamine to NA.
Heroin Opoids (Depressants) / Activation of opioid receptors (Gi, G protein) to decrease presynaptic calcium channel opening and increase postsynaptic potassium channel opening. Also decreases activation of GABA and thus disinhibits dopamine to NA.
Coedine Opoids (Depressants) / Activation of opioid receptors (Gi, G protein) to decrease presynaptic calcium channel opening and increase postsynaptic potassium channel opening. Also decreases activation of GABA and thus disinhibits dopamine to NA.
Oxycodone Opoids (Depressants) / Activation of opioid receptors (Gi, G protein) to decrease presynaptic calcium channel opening and increase postsynaptic potassium channel opening. Also decreases activation of GABA and thus disinhibits dopamine to NA.
Fentanyl Opoids (Depressants) / Activation of opioid receptors (Gi, G protein) to decrease presynaptic calcium channel opening and increase postsynaptic potassium channel opening. Also decreases activation of GABA and thus disinhibits dopamine to NA.
Alprazolam Benzodiazepines (Depressants) / Positive allosteric modulator at GABA-a receptors acting to enhance the frequency of channel opening in response to GABA. Enhanced sensory perceptions, feeling of social closeness, amnesia.
Diazepam Benzodiazepines (Depressants) / Positive allosteric modulator at GABA-a receptors acting to enhance the frequency of channel opening in response to GABA. Enhanced sensory perceptions, feeling of social closeness, amnesia.
Lorazepam Benzodiazepines (Depressants) / Positive allosteric modulator at GABA-a receptors acting to enhance the frequency of channel opening in response to GABA. Enhanced sensory perceptions, feeling of social closeness, amnesia.
GHB (Gamma-hydroxybutyric acid) Depressant / Agonist at GABA-B receptors / Euphoria, enhanced sensory perceptions, feeling of social closeness, amnesia.
Alcohol Depressant / Many actions including GABA-A allosteric modulator.
LSD Hallucinogens / 5-HT2A receptors in prefrontal cortex
PCP Hallucinogens / Block NBMA glutamate receptor
Ketamine Hallucinogens / Block NBMA glutamate receptor
Marijuana Cannabinoids / Bind CB1 receptor in brain to inhibit release of glutamate or GABA
THC Cannabinoids / Bind CB1 receptor in brain to inhibit release of glutamate or GABA
K2/Spice Cannabinoids / Bind CB1 receptor in brain to inhibit release of glutamate or GABA
Created by: carchase
 

 



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