Question | Answer |
Amitriptyline | TCA (Tertiary) /
Primarily Serotonin & NE reuptake inhibitors /
Very dirty and affects lots of receptors /
BBW: Increase risk of suicide in persons <25/
Interact with MAOI by increasing risk for serotonin syndrome |
Nortriptyline | TCA (Secondary from amitriptyline) /
Primarily NET inhibitors/
Very dirty and affects lots of receptors /
BBW: Increase risk of suicide in persons <25 /
Interact with MAOI by increasing risk for serotonin syndrome |
Clomipramine | TCA (Tertiary) /
Primarily Serotonin & NE reuptake inhibitors /
Very dirty and affects lots of receptors /
BBW: Increase risk of suicide in persons <25/
Interact with MAOI by increasing risk for serotonin syndrome |
Imipramine | TCA (Tertiary) /
Primarily Serotonin & NE reuptake inhibitors /
Very dirty and affects lots of receptors /
BBW: Increase risk of suicide in persons <25/
Interact with MAOI by increasing risk for serotonin syndrome |
Desipramine | TCA (Secondary from imipramine) /
Primarily NET inhibitors /
Very dirty and affects lots of receptors /
BBW: Increase risk of suicide in persons <25/
Interact with MAOI by increasing risk for serotonin syndrome |
Fluoxetine | SSRI /
Depression 1st line treatment & most commonly prescribed antidepressant group /
Fewer side effects and safer than TCAs /
Interact with MAOI by increasing risk for serotonin syndrome /
Exemption from BBW for MDD and OCD |
Sertraline | SSRI /
Depression 1st line treatment & most commonly prescribed antidepressant group /
Fewer side effects and safer than TCAs /
Interact with MAOI by increasing risk for serotonin syndrome /
Exemption from BBW for OCD |
Paroxetine | SSRI /
Depression 1st line treatment & most commonly prescribed antidepressant group /
Fewer side effects and safer than TCAs /
BBW: Increase risk of suicide in persons <25 /
Interact with MAOI by increasing risk for serotonin syndrome |
Citalopram | SSRI /
Depression 1st line treatment & most commonly prescribed antidepressant group /
Fewer side effects and safer than TCAs /
BBW: Increase risk of suicide in persons <25 /
Interact with MAOI by increasing risk for serotonin syndrome |
Venlafaxine | SNRI /
Dose dependent, at low dose is a SERT inhibitor, as get higher inhibits SERT/NET/DAT /
BBW: Increase risk of suicide in persons <25 /
Interact with MAOI by increasing risk for serotonin syndrome |
Duloxetine | SNRI /
BBW: Increase risk of suicide in persons <25 /
Interact with MAOI by increasing risk for serotonin syndrome |
Phenelzine | MAOI /
Irreversibe, nonspecific inhibitors of MAO /
May precipitate mania & cause weight gain /
Avoid cheese, beer, wine |
Tranylcypromine | MAOI /
Irreversibe, nonspecific inhibitors of MAO /
May precipitate mania & cause weight gain /
Avoid cheese, beer, wine |
Bupropion | Atypical antidepressant /
Weak inhibitor of SERT, NET, DAT, some nicotinic antagonist effects /
Can be used for smoking cessation /
No effect on heart,few muscarinic adverse effects, no sexual dysfunction /
BBW: Increase risk of suicide in persons <25 |
Mirtazepine | Atypical antidepressant /
Blocks presynaptic alpha2 adrenergic autoreceptors, postsynaptic seratonin2&3 receptors, antihistamine /
BBW: Increase risk of suicide in persons <25 |
Trazodone | Atypical antidepressant /
Blocks presnaptic seratonin1 autoreceptors, weak inhibition of SERT, block seratonin2 receptors /
BBW: Increase risk of suicide in persons <25 |
Lithium | Mood stabilizer /
Used for Bipolar /
Contraindicated in pregnancy /
Hard to keep in TR |
Carbamazepine | Antiepileptic Drug /
Used for Bipolar /
Prolongs the inactivated state of Na+ channels. Suppresses Ca influx. /
Contraindicated in pregnancy (neural tube defects) /
Sever liver toxicity |
Valproic Acid | Antiepileptic Drug /
Used for Bipolar /
Prolongs the inactivated state of Na+ channels. Suppresses Ca influx. /
Contraindicated in pregnancy (neural tube defects) |
Haloperidol | Typical High Potency Antipsychotic /
Blockade of D2 receptors /
Can cause extrapyramidal side effects but low interactions elsewhere /
Can be used for Schizophrenia |
Chlorpromazine | Typical Low Potency Antipsychotic
Blockade of D2 receptors /
Rarely causes extramidal side effects but high sedation /
Can be used for Bipolar & Schizophreni |
Clozapine | Atypical Antipsychotic /
Antagonist of D1, D4, antagonist of serotonin receptors /
Extrapyramidal effects are uncommon |
Aripiprazole | Atypical Antipsychotic /
Partial agonist at D2, antagonist at certain serotonin receptors |
Olanzapine | Atypical Antipsychotic /
Antagonist of serotonin receptors, some limited D2 blockage |
Quetiapine | Atypical Antipsychotic /
Antagonist of serotonin receptors, some limited D2 blockage /
Can be crushed/snorted, coinjected with cocaine. |
Resperidone | Atypical Antipsychotic /
Antagonist of serotonin receptors, some limited D2 blockage |
Ziprasidone | Atypical Antipsychotic /
Antagonist of serotonin receptors, some limited D2 blockage |
Buspirone | Serotonin Agonist /
Partial agonist at serotonin1A receptors. Does not bind GABA receptors /
Used to treat GAD /
Delayed action |
Lorazepam | Benzodiazepine /
Positive allosteric modulator at GABAA receptor enhance frequency of channel opening in response to GABA /
Fast acting for anxiety /
Risk of dependence and tolerance /
Cause confusion (CNS depression) /
BBW for respiratory depression |
Alprazolam | Benzodiazepine /
Positive allosteric modulator at GABAA receptor enhance frequency of channel opening in response to GABA /
Fast acting for anxiety /
Risk of dependence and tolerance /
Cause confusion (CNS depression) /
BBW for respiratory depression |
Diazepam | Benzodiazepine /
Positive allosteric modulator at GABAA receptor enhance frequency of channel opening in response to GABA /
Fast acting for anxiety /
Risk of dependence and tolerance /
Cause confusion (CNS depression) /
BBW for respiratory depression |
Flumazenil | Benzodiazepine antagonist /
Shorten recovery following anesthesia with benzodiazepines |
Phenobarbital | Barbiturate /
Allosteric agonist at GABAa. Enhance duration of channel opening in response to GABA. /
Impaired cognitive and motor functioning, small TI. |
Pentobarbital | Barbiturate /
Allosteric agonist at GABAa. Enhance duration of channel opening in response to GABA. /
Impaired cognitive and motor functioning, small TI. |