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Mental Drugs

Antidepressants, Bipolar Treatments, Antiphsychotics, Anxiolytics

QuestionAnswer
Amitriptyline TCA (Tertiary) / Primarily Serotonin & NE reuptake inhibitors / Very dirty and affects lots of receptors / BBW: Increase risk of suicide in persons <25/ Interact with MAOI by increasing risk for serotonin syndrome
Nortriptyline TCA (Secondary from amitriptyline) / Primarily NET inhibitors/ Very dirty and affects lots of receptors / BBW: Increase risk of suicide in persons <25 / Interact with MAOI by increasing risk for serotonin syndrome
Clomipramine TCA (Tertiary) / Primarily Serotonin & NE reuptake inhibitors / Very dirty and affects lots of receptors / BBW: Increase risk of suicide in persons <25/ Interact with MAOI by increasing risk for serotonin syndrome
Imipramine TCA (Tertiary) / Primarily Serotonin & NE reuptake inhibitors / Very dirty and affects lots of receptors / BBW: Increase risk of suicide in persons <25/ Interact with MAOI by increasing risk for serotonin syndrome
Desipramine TCA (Secondary from imipramine) / Primarily NET inhibitors / Very dirty and affects lots of receptors / BBW: Increase risk of suicide in persons <25/ Interact with MAOI by increasing risk for serotonin syndrome
Fluoxetine SSRI / Depression 1st line treatment & most commonly prescribed antidepressant group / Fewer side effects and safer than TCAs / Interact with MAOI by increasing risk for serotonin syndrome / Exemption from BBW for MDD and OCD
Sertraline SSRI / Depression 1st line treatment & most commonly prescribed antidepressant group / Fewer side effects and safer than TCAs / Interact with MAOI by increasing risk for serotonin syndrome / Exemption from BBW for OCD
Paroxetine SSRI / Depression 1st line treatment & most commonly prescribed antidepressant group / Fewer side effects and safer than TCAs / BBW: Increase risk of suicide in persons <25 / Interact with MAOI by increasing risk for serotonin syndrome
Citalopram SSRI / Depression 1st line treatment & most commonly prescribed antidepressant group / Fewer side effects and safer than TCAs / BBW: Increase risk of suicide in persons <25 / Interact with MAOI by increasing risk for serotonin syndrome
Venlafaxine SNRI / Dose dependent, at low dose is a SERT inhibitor, as get higher inhibits SERT/NET/DAT / BBW: Increase risk of suicide in persons <25 / Interact with MAOI by increasing risk for serotonin syndrome
Duloxetine SNRI / BBW: Increase risk of suicide in persons <25 / Interact with MAOI by increasing risk for serotonin syndrome
Phenelzine MAOI / Irreversibe, nonspecific inhibitors of MAO / May precipitate mania & cause weight gain / Avoid cheese, beer, wine
Tranylcypromine MAOI / Irreversibe, nonspecific inhibitors of MAO / May precipitate mania & cause weight gain / Avoid cheese, beer, wine
Bupropion Atypical antidepressant / Weak inhibitor of SERT, NET, DAT, some nicotinic antagonist effects / Can be used for smoking cessation / No effect on heart,few muscarinic adverse effects, no sexual dysfunction / BBW: Increase risk of suicide in persons <25
Mirtazepine Atypical antidepressant / Blocks presynaptic alpha2 adrenergic autoreceptors, postsynaptic seratonin2&3 receptors, antihistamine / BBW: Increase risk of suicide in persons <25
Trazodone Atypical antidepressant / Blocks presnaptic seratonin1 autoreceptors, weak inhibition of SERT, block seratonin2 receptors / BBW: Increase risk of suicide in persons <25
Lithium Mood stabilizer / Used for Bipolar / Contraindicated in pregnancy / Hard to keep in TR
Carbamazepine Antiepileptic Drug / Used for Bipolar / Prolongs the inactivated state of Na+ channels. Suppresses Ca influx. / Contraindicated in pregnancy (neural tube defects) / Sever liver toxicity
Valproic Acid Antiepileptic Drug / Used for Bipolar / Prolongs the inactivated state of Na+ channels. Suppresses Ca influx. / Contraindicated in pregnancy (neural tube defects)
Haloperidol Typical High Potency Antipsychotic / Blockade of D2 receptors / Can cause extrapyramidal side effects but low interactions elsewhere / Can be used for Schizophrenia
Chlorpromazine Typical Low Potency Antipsychotic Blockade of D2 receptors / Rarely causes extramidal side effects but high sedation / Can be used for Bipolar & Schizophreni
Clozapine Atypical Antipsychotic / Antagonist of D1, D4, antagonist of serotonin receptors / Extrapyramidal effects are uncommon
Aripiprazole Atypical Antipsychotic / Partial agonist at D2, antagonist at certain serotonin receptors
Olanzapine Atypical Antipsychotic / Antagonist of serotonin receptors, some limited D2 blockage
Quetiapine Atypical Antipsychotic / Antagonist of serotonin receptors, some limited D2 blockage / Can be crushed/snorted, coinjected with cocaine.
Resperidone Atypical Antipsychotic / Antagonist of serotonin receptors, some limited D2 blockage
Ziprasidone Atypical Antipsychotic / Antagonist of serotonin receptors, some limited D2 blockage
Buspirone Serotonin Agonist / Partial agonist at serotonin1A receptors. Does not bind GABA receptors / Used to treat GAD / Delayed action
Lorazepam Benzodiazepine / Positive allosteric modulator at GABAA receptor enhance frequency of channel opening in response to GABA / Fast acting for anxiety / Risk of dependence and tolerance / Cause confusion (CNS depression) / BBW for respiratory depression
Alprazolam Benzodiazepine / Positive allosteric modulator at GABAA receptor enhance frequency of channel opening in response to GABA / Fast acting for anxiety / Risk of dependence and tolerance / Cause confusion (CNS depression) / BBW for respiratory depression
Diazepam Benzodiazepine / Positive allosteric modulator at GABAA receptor enhance frequency of channel opening in response to GABA / Fast acting for anxiety / Risk of dependence and tolerance / Cause confusion (CNS depression) / BBW for respiratory depression
Flumazenil Benzodiazepine antagonist / Shorten recovery following anesthesia with benzodiazepines
Phenobarbital Barbiturate / Allosteric agonist at GABAa. Enhance duration of channel opening in response to GABA. / Impaired cognitive and motor functioning, small TI.
Pentobarbital Barbiturate / Allosteric agonist at GABAa. Enhance duration of channel opening in response to GABA. / Impaired cognitive and motor functioning, small TI.
Created by: carchase