Question | Answer |
target phenytoin level | 10-20 mg/dL |
HLA-B*1502 and HLA-A*3101 are gene mutations associated with increased risk of using which seizure medication | CBZ - HLA-B*1502 increases risk of steven johnson syndrome. most common in asians and indian patients TESTING RECOMMENDED. HLA-A*3101 increase in hypersensitivity syndrom e and maculopapular rash. north european and japanese mnostly. TESTING NOT REC. |
conversion of fosphenytoin to phenytoin equivalents | 1 mg phenytoin = 1.5 mg fosphenytoin= 1 mg phenytoin equivalents |
max infusion rate for phenytoin | 150 mg PE/min |
emergent drugs for status epilepticus. give to stop seizure. | diazepam, lorazepam or midazolam |
urgent drugs for status epilepticus. give after emergent meds to prevent further seizures | phenytoin, fosphenytoin, phenobarbital, valproic acid, levetiracetam, lacosamide, |
options for refractory status epilepticus | pentobarb infusion, thiopental infusion, midazolam infusion, propofol infusion |
common adverse effects for carbamazepine | hyponatremia, delayed rash, blood dyscrasias. SIADH |