| Question | Answer |
| Cardiac Glycosides (pg. 272) one drug | Digoxin |
| What does cardiac glycosides do? | Increased for of heart contraction (positive) inotropic affect)
decrease HR (negative chronotropic affect) |
| Why would we use cardiac glycosides? | HF
dysrhythmias |
| Side effects of cardiac glycosides | dysrhythmias
Cardiotoxicity |
| What is the electrolyte hat is affected by cardiac glycosides? | Potassium |
| Therapeutic serum digoxin levels | 0.5-2 ng/mL |
| Medication interactions with cardiac glycosides | Thiazide/Loop diuretics (can cause hypokalemia)
ACE/ARB can increase risk for hyperkalemia |
| Adrenergic agonists (pg 275) medications | epinephrine
dopamine
Dobutamine
Isoproterenol (catecholamine)
Terbutaline (noncatecholamine) |
| What does epinephrine do? | Alpha1 (vasoconstricts)
Beta 1 (increased HR, contractility, conduction)
Beta 2 (bronchodilation) |
| What does dopamine do? hint: different dosing (low, moderate, high) | In low dose (renal blood vessel dilation)
Moderate dosing (renal blood vessel dilation, increased HR, contractility)
High dosing (renal constriction, increased HR/contractility, vasoconstriction) |
| Side effects of epinephrine | vasoconstriction from activation of alpha1 = HTN crisis
dysrhythmias |
| Side effects of dopamine | dysrhythmias
necrosis can occur from extravasation |
| Side effects of dobutamine | increased HR |
| Medication classes that treat HF | Diuretics
ACE
ARBS
beta adrenergic blockers
Cardiac glycosides (used if above meds cannot control symptoms) |
