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Unit 4: Heart
Medications for heart failure and cardiac glycosides
Question | Answer |
---|---|
Cardiac Glycosides (pg. 272) one drug | Digoxin |
What does cardiac glycosides do? | Increased for of heart contraction (positive) inotropic affect) decrease HR (negative chronotropic affect) |
Why would we use cardiac glycosides? | HF dysrhythmias |
Side effects of cardiac glycosides | dysrhythmias Cardiotoxicity |
What is the electrolyte hat is affected by cardiac glycosides? | Potassium |
Therapeutic serum digoxin levels | 0.5-2 ng/mL |
Medication interactions with cardiac glycosides | Thiazide/Loop diuretics (can cause hypokalemia) ACE/ARB can increase risk for hyperkalemia |
Adrenergic agonists (pg 275) medications | epinephrine dopamine Dobutamine Isoproterenol (catecholamine) Terbutaline (noncatecholamine) |
What does epinephrine do? | Alpha1 (vasoconstricts) Beta 1 (increased HR, contractility, conduction) Beta 2 (bronchodilation) |
What does dopamine do? hint: different dosing (low, moderate, high) | In low dose (renal blood vessel dilation) Moderate dosing (renal blood vessel dilation, increased HR, contractility) High dosing (renal constriction, increased HR/contractility, vasoconstriction) |
Side effects of epinephrine | vasoconstriction from activation of alpha1 = HTN crisis dysrhythmias |
Side effects of dopamine | dysrhythmias necrosis can occur from extravasation |
Side effects of dobutamine | increased HR |
Medication classes that treat HF | Diuretics ACE ARBS beta adrenergic blockers Cardiac glycosides (used if above meds cannot control symptoms) |