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Unit 4: Heart

Medications for heart failure and cardiac glycosides

Cardiac Glycosides (pg. 272) one drug Digoxin
What does cardiac glycosides do? Increased for of heart contraction (positive) inotropic affect) decrease HR (negative chronotropic affect)
Why would we use cardiac glycosides? HF dysrhythmias
Side effects of cardiac glycosides dysrhythmias Cardiotoxicity
What is the electrolyte hat is affected by cardiac glycosides? Potassium
Therapeutic serum digoxin levels 0.5-2 ng/mL
Medication interactions with cardiac glycosides Thiazide/Loop diuretics (can cause hypokalemia) ACE/ARB can increase risk for hyperkalemia
Adrenergic agonists (pg 275) medications epinephrine dopamine Dobutamine Isoproterenol (catecholamine) Terbutaline (noncatecholamine)
What does epinephrine do? Alpha1 (vasoconstricts) Beta 1 (increased HR, contractility, conduction) Beta 2 (bronchodilation)
What does dopamine do? hint: different dosing (low, moderate, high) In low dose (renal blood vessel dilation) Moderate dosing (renal blood vessel dilation, increased HR, contractility) High dosing (renal constriction, increased HR/contractility, vasoconstriction)
Side effects of epinephrine vasoconstriction from activation of alpha1 = HTN crisis dysrhythmias
Side effects of dopamine dysrhythmias necrosis can occur from extravasation
Side effects of dobutamine increased HR
Medication classes that treat HF Diuretics ACE ARBS beta adrenergic blockers Cardiac glycosides (used if above meds cannot control symptoms)
Created by: anniehaas