Question | Answer |
GI motility is controlled by what? | Enteric system: serotonin, dopamine, ANS (sympathetic/parasympathetic) |
Prokinetic agents are used for what?
(increase peristalsis) | gastroparesis, GERD, postop ileus, constipation |
Cholinomimetics
mimic Ach | Bethanchol, rarely used r/t multiple cholinergic SE, activates M3 which promotes GI motility, but secretes acid |
Metoclopramide | dopamine (D2) receptor antagonist
SE: CNS-restlessness, drowsiness, EPS, coma |
Macrolides
erythromycin IV 3mg/kg | rapid tolerance, increase GI motility, used for short term |
Bulk & Stimulant laxatives that stimulate GI motility? | Bulk forming - psyllium, methycellulose Osmotic - Magnesium hydroxide, magnesium citrate, sorbitol, lactulose, Stimulant - senna, bisacodyl |
Drugs that incrase GI motility? | Cholinomimetics, Metoclopramide, Macrolides, Bulk & Stimulant laxatives |
Bethancol | Cholinomimetics that stimulate GI motility and activate M3 secreting acid, used rarely b/c SE |
This med is a dopamine (D2) receptor antagonist
with SE of CNS-restlessness, drowsiness, EPS, coma and increase GI motility? | Metoclopramide |
What is erythromycin? | macrolide ABX, rapid tolerance, increase GI motility, used for short term |
Tegaserod | increase GI motility, serotonin 5HT4 partial agonist, used for IBS-C, serious CV SE r/t interaction w/K+channels and serotonin receptor subtype = QT prolongation=arrhythmia |
increase GI motility, serotonin 5HT4 partial agonist, used for IBS-C, serious CV SE r/t interaction w/K+channels and serotonin receptor subtype = QT prolongation=arrhythmia | Tegaserod |
What are the Stimulant laxatives that promote GI motility? | Senna and Bisacodyl |
Stimulate laxatives do what? | increase peristalsis, stimulate enteric system, fluid secretion |
increase peristalsis, stimulate enteric system, fluid secretion | Stimulate laxatives: senna, bisacodyl |
What do osmotic laxatives do? | stimulate GI motility |
Magnesium citrate/hydroxide are what? | osmotic laxatives, can cause hypermagensamia so be careful with renal disease pts. |
Sorbital | class 3 potassium sparing anti-arrhythmic, osmotic laxative, non-absorbable sugar that may be metabolize by gut bacteria causing flatus (gas) |
Lactulose | reduce ammonia levels, osmotic laxative, non-absorbable sugar that may be metabolize by gut bacteria causing flatus (gas) |
Psyllium, methycellulose | bulk forming laxative, stimulate GI motility, indigestible colloids that absorb water to distend colon and promote peristalsis |