Class/MOA | Generic | Brand | Route | Side Effects | Hep B/C |
NS3/4 Protease Inhibitor | Telaprevir | Incivek | po | rash pruritus, anemia, fatigue, n/v/d, dysgeusia, anorectal irritaion/itching | C |
NS3/4 Protease Inhibitor | Simepravir | Olysio | po | rash/photosensitivity, pruritus, nausea | C |
NS5B Polymerase Inhibitor | Sofosbuvir | Sovaldi | po | fatigue, HA, nausea, insomnia | C |
| Adefovir | Hepsera | | renal dysfucntion | B |
| Entecavir | Baraclude | | n/v, dizziness, headache, fatigue | B |
| Tenofovir | Viread | | potentially renal, well tolerated | B (DOC) |
| Telbivudine | Tyzeca | | nausea, ab pain, ha, urti, malaise, fatigue, increased cpk | |
pegylated interferon (immune stimulation) | peginterferon alpha-2a | Pegasys | inj | depression, suicide, flu-like illnesses, weight loss, bone marrow depression | B/C |
pegylated interferon (immune stimulation) | peginterferon alpha-2b | Pegintron | inj | depression, suicide, flu-like illnesses, weight loss, bone marrow depression | B/C |
MOA Unknown | Ribavirin | Ribavirin | po | bone marrow suppression, anemia, n/v, diarrhea, birth defects/death of unborn child, mitochondrial toxicity | C |
NS3/4 Protease Inhibitor | Bocepravir | Victrelis | po | anemia, neutropenia, nausea, dysgeusia, diarrhea, vomiting, chills | C |
| Lamivudine | | | ear, nose, throat infections | B |