| Question | Answer |
| Metronidazoles | Nitroimidazoles - DNA damaging |
| Rifampin | Rifamycins- RNA synthesis inhibitor |
| Enfrofloxacin, ciprofloxacin, marbofloxacin, orbafloxacin | Floroquinolones - DNA replication inhibitors |
| Nitrofurantoin | Nitrofurnas - energy production pathway |
| Trimethoprim, ormetoprim | Diaminopyrimidines - folic acid pathway |
| Sulfamethoxazole, sulfadiazine, sulfadimethoxine | Sulfonamides - folic acid pathway |
| Chloramphenicol, florfenicol | Phenicols - 50 s protein synthesis inhibitor |
| Lincomycin, clindamycin, pirlimycin | Lincosamides - 50s protein synthesis inhibitor |
| Erythromycin, spiramycin, tulathromycin, tylosin, tilmicosin | Macrolides - 50 s protein synthesis inhibitors |
| Tetracycline, oxytetracyclin, chlortetracycline, doxycycline | Tetracylines- 30 s protein synthesis inhibitor |
| Streptomycin, spectinomycin, neomycin, gentamicin, amikacin | Aminoglycosides - 30 s protein synthesis inhibitors |
| Bacitracin | Bacitracin - cell wall synthesis inhibitor |
| Polymyxin B | Polymyxins - cell membrane disruptor |
| Vancomycin | Glycopeptides - inhibits cell wall synthesis |
| Aztreonam | Monbactams - B-lactam group |
| Imipenem | Carbapenems - B-lactam group |
| Clavulanic acid, sulbactam | B-lactamase inhibitors - B-lactam group |
| Ceftiofur, ceftazidime, cefovecin, ceftriaxone | 3rd generation cephalosporins |
| Cefuroxime, cefotetan | 2nd generation cephalosporins |
| Cefazolin, cephalexin, cephaloridine | 1st generation cephalosporins |
| Ticarcillin, pipercillin | Extended spectrum penicillins |
| Methacillin, oxacillin | B lactamase resistant penicillins |
| Amoxicillin, ampicillin | Aminopenicillins |
| Penicillin G, penicillin V | Basic penicillin |
| Inactivated by acidic environment | Penicillin, cephalosporins, aminoglycosides, macrolides |
| Mineral interactions | Floroquinolones, tetracyclines, aminoglycosides |
| Allergies | Penicillins, cephalosporins, nitrofurans, sulfonamides |
| Poor tissue penetration | Penicillin, aminoglycosides, nitrofurans |
| Mycoplasma treatment | Macrolides, tetracycline, floroquinolone (back up) |
| Poor oral bioactivity | Penicillin, sulbactam, bacitracin, aminoglycosides (except neomycin) |
| Bone marrow toxicity | Chloramphenicol, rifampin |
| Banned in food animals | Banned: Vancomycin, chloramphenicol, rifampin, metronidazole, nitrofuran. Banned-off label: Cephalosporin, floroquinolones, sulfonamides (dairy cattle). Aminoglycosides - vet med ban |
| Neurotoxicity | Floroquinolone and metronidazole |
| Teratogenic | Metronidazole, rifampin, vancomycin |
| NOT empirical | Extended Spectrum pen, Carbapenems, Monobactams, Glycopeptides, Fluoroquinolones, Nitrofurans |
