Question | Answer |
MOA of DMARDS | antiinflammatory effect that slowps progression and preserve joint function; exact MOA is unclear |
Name 3 DMARDS | methotrexate, sulfonamides, hydrocychloroquine(antimalarials) |
This drug has antiinflammatory and immmunosuppresive properties | methotrexate |
Agents that regulate extent and duration of the immune response and target IL and TNF | Immune Modulators |
3 things to monitor or hydroxychloroquine | opthamalogy, blood cell counts, muscle strength and knee reflexes |
3 drug classes to take care of RA | DMARDS, immunomodulators, corticosteriod |
MOA of corticosteroids with RA | inhibit production of IL (decreases the immune response through decreasing T cells) |
NP role in RA Tx | monitor for response to medication and adverse reactions |
1st line tx for RA | DMARKS early aggressively |
adverse effects of immune modulators | tb risk, risk for infections, LFTS, Cbc |
Indicator of reduced RA activity | decrease crp and esr |
HOw to monitor pt taking sulfasalzine | cbc, wbc, lft prior to, and at every 2nd weekd during the 1st 3 months of therapy, the montly x 3months, then once every 3 months |
How to monitor pts takin methotrexate | cc, albumin, creatinine, and LFA at baseline and then monthly x 6 months and then every 1-2 months |
Preg Category for hydroxyChloroquine | c |
Preg Category for methotreXate | X |
Preg Cat for sulfasalazine | B |