Drug | Brand Name | Pharmacologic Class | Therapeutic Class |
Phenoxybenzamine | Dibenzyline | irreversible a-adrenoreceptor antagonist | vasodilator |
Propranolol | Inderal | nonselective b-adrenoceptor antagonist | sympatholytic, antihypertensive |
Phentolamine | Regitine | nonselective a-adrenoceptor antagonist | vasodilator |
Atenolol | Tenormin | selective b1-adrenoreceptor antagonist | sympatholytic, antihypertensive |
Terazosin | Hytrin | selective a1-adrenoceptor antagonist | antihypertensive agent, urologic agent |
Dobutamine | Dobutrex | selective b1-adrenoceptor agonist | sympathomimetic, cardiac stimulant |
Epinephrine | Adrenalin | nonselective adrenoceptor agonist | sympathomimetic, bronchodilator, vasopressor |
Tamsulosin | Flomax | uroselective a1-adrenoceptor antagonist | urologic agent |
Edrophonium | Tensilon | cholinesterase inhibitor | diagnostic agent (for myasthenia gravis - should increase muscle weakness) |
Pyridostigmine | Mestinon | cholinesterase inhibitor, cholinergic agonist | antimyasthenic agent |
Pralidoxime | Protopam | cholinesterase reactivator (takes OP off of AChE) | organophosphate antidote |
Pilocarpine | Salagen | muscarinic ACh receptor agonist | antiglaucoma agent, sialagogue |
Atropine | Atro-Pen | muscarinic ACh receptor antagonist | anticholinergic agent |
Solifenacin | VESIcare | muscarinic receptor antagonist | overactive bladder agent |
Sildenafil | Viagra | phosphodiesterase inhibitor | vasodilator |
Rocuronium | Zemuron | nondepolarizing NM blocking agent of intermediate duration of action (30-60 min) | paralytic agent |
Succinylcholine | Anectine | depolarizing NM blocker with short duration of action (5-10 min) | paralytic agent |
a1 receptors | -vasoconstriction
-smooth muscle contraction
-iris
-GI and urinary spincters
-arrector pili | NE > E | |
a2 receptors | -negative feedback for a1 receptors | E >= NE | |
b1 receptors | -on the heart
-incr HR
-incr contractility
=incr CO | E = NE | |
b2 receptors | -smooth muscle relaxation
-BRONCHIAL TREE
-GI tract
-urinary bladder
-arteries by skeletal muscle
-some coronary arteries | E >> NE | |
muscarinic receptors | -smooth muscle contraction
-gland secretion
-lower HR back to normal | ACh | |
nicotinic receptors | -skeletal muscle contraction | ACh | |
Phenylephrine | Neo-synephrine | selective a1-adrenoceptor agonist | vasoconstrictor, decongestant |
Pseudoephedrine | Sudafed | indirect- and direct-acting adrenoceptor agonist | decongestant |