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Autonomic & NM Drugs

Autonomic and Neuromuscular Drugs

DrugBrand NamePharmacologic ClassTherapeutic Class
Phenoxybenzamine Dibenzyline irreversible a-adrenoreceptor antagonist vasodilator
Propranolol Inderal nonselective b-adrenoceptor antagonist sympatholytic, antihypertensive
Phentolamine Regitine nonselective a-adrenoceptor antagonist vasodilator
Atenolol Tenormin selective b1-adrenoreceptor antagonist sympatholytic, antihypertensive
Terazosin Hytrin selective a1-adrenoceptor antagonist antihypertensive agent, urologic agent
Dobutamine Dobutrex selective b1-adrenoceptor agonist sympathomimetic, cardiac stimulant
Epinephrine Adrenalin nonselective adrenoceptor agonist sympathomimetic, bronchodilator, vasopressor
Tamsulosin Flomax uroselective a1-adrenoceptor antagonist urologic agent
Edrophonium Tensilon cholinesterase inhibitor diagnostic agent (for myasthenia gravis - should increase muscle weakness)
Pyridostigmine Mestinon cholinesterase inhibitor, cholinergic agonist antimyasthenic agent
Pralidoxime Protopam cholinesterase reactivator (takes OP off of AChE) organophosphate antidote
Pilocarpine Salagen muscarinic ACh receptor agonist antiglaucoma agent, sialagogue
Atropine Atro-Pen muscarinic ACh receptor antagonist anticholinergic agent
Solifenacin VESIcare muscarinic receptor antagonist overactive bladder agent
Sildenafil Viagra phosphodiesterase inhibitor vasodilator
Rocuronium Zemuron nondepolarizing NM blocking agent of intermediate duration of action (30-60 min) paralytic agent
Succinylcholine Anectine depolarizing NM blocker with short duration of action (5-10 min) paralytic agent
a1 receptors -vasoconstriction -smooth muscle contraction -iris -GI and urinary spincters -arrector pili NE > E
a2 receptors -negative feedback for a1 receptors E >= NE
b1 receptors -on the heart -incr HR -incr contractility =incr CO E = NE
b2 receptors -smooth muscle relaxation -BRONCHIAL TREE -GI tract -urinary bladder -arteries by skeletal muscle -some coronary arteries E >> NE
muscarinic receptors -smooth muscle contraction -gland secretion -lower HR back to normal ACh
nicotinic receptors -skeletal muscle contraction ACh
Phenylephrine Neo-synephrine selective a1-adrenoceptor agonist vasoconstrictor, decongestant
Pseudoephedrine Sudafed indirect- and direct-acting adrenoceptor agonist decongestant
Created by: jcechter