Question | Answer |
Zidovudine | Nucleoside Reverse Transcriptase
Can be used in pregnancy-given to mom then kid for 3 weeks
Not compatible with stavudine |
Didanosine | Nucleoside Reverse Transcriptase
Peripheral Neuropathy, pancreatitis |
Lamivudine | Nucleoside Reverse Transcriptase
Treats Hepatitis B
=Hep B flare when withdrawn |
Abacavir | Nucleoside Reverse Transcriptase
Sever hypersensitivity reactions |
Emtricitabine | Nucleoside Reverse Transcriptase
Lamivudine Analog
Treats Hepatitis B
Cause Hyperpigmentation of Palms/Soles
Best tolerated |
Tenofovir | Nucleotide Reverse Transcriptase
phosphorylated to nucleoside
Treats Hep B
No p450 action |
Nevirapine | Non-Nucleoside Reverse Transcriptase
Can Cause Rash |
Evfavirenz | Non-Nucleoside Reverse Transcriptase
P450 Metabolism
Neural tube defects
Long half life |
Ritonavir | Protease Inhibitors
P450 |
Indinavir | Protease Inhibitors
P450
Nephrolithiasis, skin issues |
Nelfinavir | Protease Inhibitors
P450
most common used |
Atazanavir | Protease Inhibitors
P450
abnormal fat distribution |
Albendazole | Antihelminthic
Inhibits Microtubule Glucose Transport
1st line all the time |
Pyrantel | Antihelminthic
Activates cholinergics, depolarizing neuromuscular blockade.
OTC |
Praziquantel | Antihelminthic-Cestodes
Causes Spastic contraction then paralysis due to calcium influx
disloges jaw in cestodes.
Give Mg 15-30g 2 hrs post treatment |
Metronidazole | Antiprotozoal
Symptomatic, Not for use as a contact or luminal Amebicide
Inhibits DNA synthesis |
Iodoquinol | Antiprotozoal
Not absorbed, used for luminal
Combined with metronidazole
Unknown MOA |
Paromomycin | Antiprotozoal
Aminoglycoside, inhibits protein synthesis binds 30s ribosome
Cryptosporidiosis treatment in AIDS patients |
Niazoxanide | Antiprotozoal
Hydrolyzed to active metabolite.
Interferes with anaerobic respiration
Treats diarrhea from cryptosporidium parvum and Giardia lamblia |
Chloroquine | Antimalarial
Interferes with feeding mechanism
GI upset, retinopathy, allergic reactions.
once/week dose for prophylaxis
high dose, hydroxychloriquine for rheumatoid/lupus |
Quinine/Quinidine | Antimalarial
treats chloroquine resistant.
interferes with feeding, more toxic not for proph |
Mefloquine | Antimalarial
treats resistant
Psychotic/Epileptic effects |
Artemisinin/Artemether | Antimalarial
Primary for resistan falciparum.
Generates free radicals |
Primaquine | Antimalarial
Treats tissue infections
Used for follow up therapy |
Pyrimethamine | Antimalarial
Anti folate
Skin Rashes and Bone marrow suppression |
Proguanil | Antimalarial
Antifolate
treatment and prophylaxis, not in US |
Pyrimethamine + Sulfadioxone | Antimalarial
PABA blockade and antifolate |
Atovaquone + proguanil | Antimalarial
Antifolate + inhibition of electron transport |
Doxycycline | Antimalarial
Phototoxicity, discoloration of teeth in children
Not for children and pregnant women |
Dexamethasone | given during neurocysticercosis treatment |