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Pharm3test3

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Created by: amarche1

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State symbols

Question	Answer
Zidovudine	Nucleoside Reverse Transcriptase Can be used in pregnancy-given to mom then kid for 3 weeks Not compatible with stavudine
Didanosine	Nucleoside Reverse Transcriptase Peripheral Neuropathy, pancreatitis
Lamivudine	Nucleoside Reverse Transcriptase Treats Hepatitis B =Hep B flare when withdrawn
Abacavir	Nucleoside Reverse Transcriptase Sever hypersensitivity reactions
Emtricitabine	Nucleoside Reverse Transcriptase Lamivudine Analog Treats Hepatitis B Cause Hyperpigmentation of Palms/Soles Best tolerated
Tenofovir	Nucleotide Reverse Transcriptase phosphorylated to nucleoside Treats Hep B No p450 action
Nevirapine	Non-Nucleoside Reverse Transcriptase Can Cause Rash
Evfavirenz	Non-Nucleoside Reverse Transcriptase P450 Metabolism Neural tube defects Long half life
Ritonavir	Protease Inhibitors P450
Indinavir	Protease Inhibitors P450 Nephrolithiasis, skin issues
Nelfinavir	Protease Inhibitors P450 most common used
Atazanavir	Protease Inhibitors P450 abnormal fat distribution
Albendazole	Antihelminthic Inhibits Microtubule Glucose Transport 1st line all the time
Pyrantel	Antihelminthic Activates cholinergics, depolarizing neuromuscular blockade. OTC
Praziquantel	Antihelminthic-Cestodes Causes Spastic contraction then paralysis due to calcium influx disloges jaw in cestodes. Give Mg 15-30g 2 hrs post treatment
Metronidazole	Antiprotozoal Symptomatic, Not for use as a contact or luminal Amebicide Inhibits DNA synthesis
Iodoquinol	Antiprotozoal Not absorbed, used for luminal Combined with metronidazole Unknown MOA
Paromomycin	Antiprotozoal Aminoglycoside, inhibits protein synthesis binds 30s ribosome Cryptosporidiosis treatment in AIDS patients
Niazoxanide	Antiprotozoal Hydrolyzed to active metabolite. Interferes with anaerobic respiration Treats diarrhea from cryptosporidium parvum and Giardia lamblia
Chloroquine	Antimalarial Interferes with feeding mechanism GI upset, retinopathy, allergic reactions. once/week dose for prophylaxis high dose, hydroxychloriquine for rheumatoid/lupus
Quinine/Quinidine	Antimalarial treats chloroquine resistant. interferes with feeding, more toxic not for proph
Mefloquine	Antimalarial treats resistant Psychotic/Epileptic effects
Artemisinin/Artemether	Antimalarial Primary for resistan falciparum. Generates free radicals
Primaquine	Antimalarial Treats tissue infections Used for follow up therapy
Pyrimethamine	Antimalarial Anti folate Skin Rashes and Bone marrow suppression
Proguanil	Antimalarial Antifolate treatment and prophylaxis, not in US
Pyrimethamine + Sulfadioxone	Antimalarial PABA blockade and antifolate
Atovaquone + proguanil	Antimalarial Antifolate + inhibition of electron transport
Doxycycline	Antimalarial Phototoxicity, discoloration of teeth in children Not for children and pregnant women
Dexamethasone	given during neurocysticercosis treatment