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exceptients

ceutics

QuestionAnswer
most frequently dispensed dosage form in the US tablets
tablets are prepared primarily by compression
what addes the neccessary bulk to a formulation to prepare tablets of the desired size diluents and Fillers
which promatoes adhesion of the particles of the formulation, allowing a granualtion to be prepared and maintaining the integrity of the final tablet binders and adhesive
what promotes breakup of the tablets after adminsistration to smaller particles for ready drug availbility disintegrants
what enhance the flow of the material into the tablet dies, minimize wear of the punches and dies, prevent fill material from sticking to the punches and dies, and produce tablets with sheen antiadherents, glidants, lubricants or lubricating agents
prepared by subjecting the fill material to more than a single compression multiply compressed tablets (def)
lyophilization zydis technology R.P. Scherer Claritin
soft direct compression wow-tab technology by yamomouchi Pharma Benadryl Fastmelt
mask taste in dissolving tablets by surrounding particles by a coat micoroencapsulation and nanoencapsulation
QC meassure where by you take the avg. weight of 10 tablets weight variation test
QC meassure where by you assay 10 dosage units and it must lie b/w 85%-115% SD of <6% content uniformity test
QC meassure where by you measure tablets with vernier caliper, hand gauge, or automate equ. tablet thickness test
QC meassure where by you meassure the amount of pressure applied to make the tablet tablet hardness
QC meassure where by you rotate tablets and compare weight loss must not be >1% tablet friability
QC meassure where you put the drug through cycles in immersion fluid and record time tablet disintegration
QC meassure where by you look at scale up batches of 10% or 100,000 dosage units whichever greater and predict IVIVC correlation solubility and permeability tablet dissolution
Created by: lainylaina
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