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AED+ Side Effects

1

QuestionAnswer
Carbamazepine *Some Weight Gain *Rash ~Also: Fatigue, vision changes, nausea, dizziness, tics, nystagmus, gastric upset, photosensitivity, confusion, aggression, drowsiness, HA, coordination, greatly decreases alcohol tolerance, and rarely Stevens-Johnson's Syndrome
Ethosuximide *Bone Marrow Depression ~Also: Nausea, vomiting, decreased appetite, and weight loss.
Felbamate *Liver Toxicity ~Also: Decreased appetite, weight loss, inability to sleep, HA, depression, liver failure. No longer used or limited and pts must have blood cell counts and liver tests regularly.
Tiagabine Dizziness, fatigue, weakness, irritability, anxiety, and confusion.
Levetiracetam *Moodiness *Irritability ~Also: Tiredness, weakness, and behavioral changes. Not metabolized by the liver so it won't interfere with those that are.
Pregabalin Dizziness, sleepiness (somnolence), dry mouth, peripheral edema, blurred vision, weight gain, and difficulty with concentration/attention.
Gabapentin Few lasting side effects; during the first weeks of tx, may experience tiredness and dizziness. Not metabolized by liver like others so won't interfere. Little toxicity in very large doses. Clearance was rapid with minimal symptoms in suicide attempt.
Phenytoin *Fetal Hydantoin/Dilantin Syndrome (Defects caused to fetus.) *Lupus-Like Syndrome *Gingival Hyperplasia *Coarsity of Features *Hirsutism ~Also: Skin eruptions, neuropathy, fatigue, slurred speech, bone thinning, Stevens-Johnson's, lymphoma.
Topiramate *Glaucoma *Weight Loss *Hyperthermia ~Also: Sleepiness, dizziness, speech problems (aphasia and shuddering), nervousness, memory problems, vision problems, and kidney stones.
Oxcarbazepine *Constipation *Some Memory Defect ~Also: Tiredness, dizziness, headache, blurred or double vision.
Valproate *Weight Gain *Osteoporosis *Menstrual Irregularity *Pancreatitis *Teratogenicity (fetal malformation) ~Also: Nausea, vomiting, tremor, hair loss, easy bruising, depression adults, irritability, attention, cognitive, swell of ankles, hearing loss, cl
Zonisamide Drowsiness, dizziness, unsteady gait, kidney stones, abdominal discomfort, headache, and rash.
Benzodiazephines Tiredness, unsteady walking, nausea, depression, and loss of appetite. In children, they can cause drooling and hyperactivity. Has sedative effect, Impairs motor function.
Clonazepam *Sedation ~Also: Drowsiness, interference with cognitive, motor performance, euphoria. Sedation reported in approximately half of pts, dizziness reported in one-third of pts, weakness, and unsteadiness.
Lamotrigine *Stevens–Johnson's Syndrome *Insomnia ~Also: Diplopia, drowsiness, ataxia, HA common but usually minimal side effects. DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms), toxic epidermal necrolysis, which is increased with VA.
Lacosamide Dizziness, nausea, vomiting, depression, suicidal thoughts or behaviors, arrhythmia, fainting, heart palpitations, allergic reaction, including an unexplained rash, hives, itching, unexplained swelling, wheezing, or difficulty breathing or swallowing.
Lorazepam *Sedation *Respiratory Depression in High Doses ~Also: Dizziness, weakness, unsteadiness, depression, suicidal thoughts, seizures, anxiety, excitation or agitation, hostility, aggression or rage, insomnia, hallucinations, signs of an allergic rxn.
Barbituates CNS depression, additive effects, depressed respiration, impaired motor skills, drowsiness.
Clobazam *Sedation ~Also: Drowsiness, interference with cognitive and motor performance, euphoria (intense feelings).
Guanfacine *Sleepy ~Also: Dizziness, drowsiness, headache, depression, constipation, gas pains, diarrhea, loss of appetite, fatigue, and nasal congestion.
Methylphenidate *Decreased Appetite *Insomnia *Motor Tics ~Also: Nervousness, drowsiness.
Amphetamine *Decreased Appetite *Insomnia *Motor Tics ~Also: Can cause severe weight loss and dependence just in pharmaceutical form. Other forms may increase dependency and heart rate to dangerous levels.
Atomoxetine Dry mouth, tiredness, irritability, nausea, decreased appetite, constipation, dizziness, sweating, dysuria, decreased libido, urinary retention, increased obsessive behavior, weight changes, slowed growth in children, palpitations, increases in HR and BP.
Lisdexamfetamine Dimesylate Loss of appetite, weight loss, sleep problems (insomnia), nausea, vomiting, stomach pain, irritability, mild skin rash, dry mouth/unpleasant taste in mouth.
Clonidine *Sedation *May Lower Blood Pressure ~Also: Lightheadedness, dry mouth, dizziness and constipation.
Dextromethorphan Dizziness; drowsiness; stomach upset. FDA issued a safety alert about certain unapproved prescription of this products containing this drug in combination with other drugs.
Risperidone *Weight Gain *Sedation *Increased Prolactin *Gynecomastia *Hyperglycemia ~Also: Drowsiness, HA, digestive, increased dream activity, sleep, appetite, sexual problems, skin changes, pain, weight loss, Tardive dyskinesia. Possibly more effects in b
Anti-Depressants Sedation, decrease in response, drowsiness, inability to converse.
Dopamine Coreiform mvts, depression, paranoia, suicidal tendencies, anorexia.
Amphetamines Hypertension, irritability, anxiety, physical dependence, psych dependence.
Diazepam *Sedation *Possible Respiratory Depression ~Also: or CNS Depression, hypotension when administered parenterally, especially when used in conjunction with other AEDs.
Phenobarbitol *Sedation *Respiratory Depression in High Doses ~Also: Possible neuro-psychologic effects, drowsiness, behavior changes, subtle cognitive effects, memory, perception, irritability, hyperkinesia, depression.
Primidone *Sedation ~Also: High incidence of toxicity at start. Sedation is common but often diminishes with continued administration.
Vigabatrin *Visual Field Deficits
ACTH *Weight Gain *Steroid Psychosis *Cataract *Brain Atrophy
Midazolam *Sedation
Butalbital *Sedation
Compazine *Sedation
Primozide *Prolonged Q-T
Clorazepate *Bone Marrow Depression *Sedation
Cyproheptadine Weight gain.
Created by: kmburg5840