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pharm-cardio

Question
MOA of Thiazide Diuretics i.e. Hydrochlorothiazide Inhibition of NA-Cl cotransporter in the early distal segment of the loop of henle. Also inhibition of the Ca-Mg antiport. Stimulation of RAAS pathway
Why does a THIGH belong to a HEN? The clnical uses of thiazides are Hypertension, Edema (cardiogenic, nephrogenic, or hepatogenic) Nephrolithiasis (calcium), osteoporosis in pt
MOA of Thiazide Diuretics i.e. Hydrochlorothiazide Inhibition of NA-Cl cotransporter in the early distal segment of the loop of henle. Also inhibition of the Ca-Mg antiport. Stimulation of RAAS pathway
Why does a THIGH belong to a HEN? The clnical uses of thiazides are Hypertension, Edema (cardiogenic, nephrogenic, or hepatogenic) Nephrolithiasis (calcium), osteoporosis in pts w/hypercalciuria. Nephrogenic diabetes insipidus (what a hydro-closing thiazide!
Thiazide side effects HypoNatremia, chloremia, tension, volume depletion. HypoKalemic metabolic alkalosis. HYPER-Ca, Mg, uricemia, glycemia, lipids, sensitivity.
What is the nonpharmacoloigcal approach to HTN weight loss, reduction of NA intake , increase aerobic exercise, moderate consumption of alcohol
What is the pharmacotherapy approach to HTN? diuretics, sympatholytic drugs, Ca channel blockers, ACE inhibitors and ARBS, vasodilators
What are the 3 types of diuretics Thiazides, loop diuretics, K sparing agents
What diuretic has a side effect of torsades de pointes? Benzothiadiazines
What are the K sparing diuretics? Spironolactone, Triamterene, amiloride
Inhibit NA-Cl pump thiazides
Inhibit NA channels on luminal membrane Triamterene and Amiloride
Adverse effects of BB for HTN with Avoided in asthmatic pts, pts with av nodal dysfunction. use with caution in diabetic
MoA for ACEI Inhibit the production of ANG II. Blunt the effect of aldosterone. Enhance the effectsof diuretics. Help to prevent K wasting especially when used with K sparing agents.
MoA for ARBS Relax smooth muscle. Increase renal salt and water excretion. Decrease cellular hypertrophy.
Created by: emorgan03
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