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Opioid

Mod 4

QuestionAnswer
MORPHINE Full Agonist
MEPERIDINE Full Agonist
METHADONE Full Agonist treat addicts euphoria not as great
PENTAZOCINE Mixed Agonist-antagonist kappa, delta abuse potential Talwin = aspirin Talacen = acetminophen
BUPRENORPHINE Mixed Agonist-antagonist high Mu
OXYCODONE Partial Agonist
CODEINE Partial Agonist Tylenol 2,3,4 - w/ acetaminophen
HYDROCODONE Partial Agonist w/ acetaminophen hycodan = infant
PROPOXYPHENE Partial Agonist
NALOXONE Antagonist short duration
NALTREXONE Antagonist long duration preferred treat alcoholism
TRAMADOL Opioid and antidepressant cross increase NE 5HT, weak mu
Metabolism of Opioid Hepatic viz conjugation with glucoronic acid mostly in kidney and some in bile most do not cross blood brain barrier
Adverse effects of Opioid miosis respiratory and cardiac depression sedation nausea and vomiting constipation postural hypotension tolerance and physical dependence
What is the mechanism of Tolerance? G-protein system- ligand binds at C-terminus -> recruit B arrestins - in clathrin coated pit ->inactivate more pits with more drugs
Created by: prinny916
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