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Insulin Drugs

Mod 2

QuestionAnswer
Mechanism of Insulin glucose + aa. -> increase ATP -> inhibit K channels -> depolarize cell -> Ca channels Open, Ca IN -> exocytosis of insulin
Insulin receptor a subunit - hormone binding b subunit - protein tyrosine kinase stimulate
What distinct carrier is the most important regulator of glucose transport into muscle, fat and blood glucose levels GLUT4
What are the naturally-occuring commercial sources of insulin procine and bovine pancreas
What are ultra-short acting Insulin drugs? Insulin Lispro Insulin Aspart (infusion pump) INsulin Glulisine
What are short acting Insulin Drugs? Insulin Injection
What are Intermediate Acting Insulin Drugs? Isophane Insulin Suspension (NPH insulin) mixture NPH/insulin Humulin (70/30 or 50/50)
What are Long Acting Insulin Drugs? Insulin Detemir myristic and zinc stimulates formulation of hexamers and dihexamers - stable, long reaction - bound detemir wont enter systemic circulation and inactive
What are the 2 main organs that remove insulin from circulation? liver kidney (more)
What are adverse effects of insulin drugs? hypoglycemia allergic reactions insulin resistance lipohypertrophy weight gain blurred vision
Created by: prinny916
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