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Stroke

Mod 4

QuestionAnswer
What artery provides vision? Posterior Cerebral Artery
What are the types of strokes? ischemic thrombotic embolic hemorrhagic
What are the types of Hemorrhagic Strokes? Subarachnoid Intracerebral
What is the treatment for Subarachnoid Stroke? excise it in surgery
What is the cause of Intracerebral Hemorrhage? rupture vessels cause bleeding into brain parenchyma
What are 3 ways to reduce risk of stroke? aspirin - reduce risk of thrombus Vitamin E Omega-3 POlyunsaturated FA
What is the mechanism for T-PA? binds to plasminogen within clot and convert it to plasmin -> lyse fibrin tangles and fibrinogen effective first 3 hours after stroke.
Adverse Effects of TPA Bleeding
Explain Excitotoxicity quick replenish of oxygen to deoxygenated tissue can cause apoptosis (Toxic Cascade) (no O2)glutamate -> activation of NMDA receptor -> (sweeling) Na, H2O, Ca postsynape-> calmodulin -> Nitrite Oxide ->cell death
What is the propose drug of the future? NMDA antagonist (MK-801) block calcium influx, GABA agonist, AMPA agonist, Ca channel blockers, reducer of Ca, inhibitor of NO, free radical scavenger, prevent glutamate release
How does NMDA receptor allow Calcium IN? DAP-K phosphorylate and cause NR2B receptor to open block phosphorylattion might prevent cell death
Created by: prinny916
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