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GI Drugs

Mod 2

QuestionAnswer
What are the characteristics of Proton-Pump Inhibitors? irreversibly inhibit H+/K+ ATPase pump ->decrease gastric acid give on empty stomach Long term adverse effects decreased B12 increase risk of pneumonia and fracture
What are the characteristics of Bulk-Forming Laxative? stimulate peristalsis - fibrous ball esophageal/intestinal obstruction
What are the characteristics of Adsorbent? Relief of diarhea act like a sponge
What are Stool Softeners? DOCUSATE SODIUM DOCUSATE CALCIUM DOCUSATE SODIUM + SENNA
What does the stimulant Senna and Bisacodyl do? intermitten use - else systemic addiction laxative-dependency, abdominal cramping, fluid and electrolyte imbalance with chronic use
What are the characteristics of Antiperistaltic? Opioid Agent inhibit GI peristalsis Antidiarrheal
What are the characteristics of H2 Antagonist? acid neutralizing capabilities nocturnal acid production binds to H2 receptors: stimulate parietal cells increasing secretion of gastric HCl and pepsin well tolerated no adverse effects
Maalox, Mylanta, Riopan, Gaviscon, Tums Rolaids Antacids chewable not swallable CO2 Biproducts increase pH-interact with many agents
CIMETIDINE H2 Antagonist Endocrine Effects interferes with CYP450 pathway treat warts
FAMOTIDINE H2 Antagonist
NIZATIDINE H2 Antagonist
RANITIDINE H2 Antagonist
LANSOPRAZOLE PPI
OMEPRAZOLE PPI
ESOMEPRAZOLE PPI proprodurg of Omeprazole
RABEPRAZOLE PPI
PANTOPRAZOLE PPI
DEXLANSOPRAZOLE PPI
METOCLOPRAMIDE Prokinetic Agent Stimulate gut motor function (cholinergic) DM w/ nerve damage to stomach given to prevent hypoglycemia EPS
SIMETHICONE antifoaming agent
PSYLLIUM Bulking-Forming Laxative Adsorbent
METHYCELLULOSE Bulking-Forming Laxative Adsorbent
POLYCARBOPHIL Bulking-Forming Laxitive
SODIUM PHOSPHATE PREPS Stimulants
POLYETHYLENE GLYCOL PREPS Stimulants acute phosphate renal failure
GLYCERIN SUPPOSITORY Stimulants Osmotic Action in rectum. safe in children
LOPERAMIDE Antiperistaltic related to narcotics
DIPHENOXYLATE + ATROPINE Antiperistaltic atropine to prevent abuse (anticholinergic)
OPIUM TINCTURE Antiperistaltic respiratory depression, narcotic abuse
BISMUTH SUBSALICYLATE Antisecretory darken tongue and stools salicylism
Created by: prinny916
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