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ECC Test 3 Antifung
| Question | Answer |
|---|---|
| Mycosis | Infection from a fungus |
| Difference between fungus and bacteria | Protective layers of fungal cell make organism resistan to antibiotics |
| Most susceptible to fungal infections | Immunosuppressant and elderly pts |
| Topical Antifungal Infections | Tinea Infections (Ring Worm), Tinea Pedis(Athletes Foot), Tinea Cruris(Jock itch) and Candida (Yeast infection) |
| Amphotericin B | Tx of progressive, potentially fatal fungal infections. Very long half life (24hours to 15 days). Do not use if lactating or have kidney disease. CAN be given to pregnant women cautiously. Adverse: R/t toxic effects on liver and kidneys |
| Systemic Antifungal Agents-Prototype | Nystatin (Nilstat) |
| Nystatin | Used for tx of intestinal Canididiasis. PO or Topical |
| Azoles Antifungals-Prototype | Fluconazole (Diflucan) |
| Fluconazole | PO,IV. Tx of Canidiasis, Cryptococcal meningitis. Phx agent in reducing incidence of Canididiasis in bone marrow transplant recipient. Do not use if renal dysfunction or pregnancy. Adverse: liver toxicity, GI. Inhibits CYP450 causing many D2D interactions |
| Ketoconazole (Nizoral) | PO. Blocks activity of a steroid in fungal wall. SE: Blocks testosterone and cortisol. Do not use if pt has endocrine or fertility problems. Adverse: Hepatic Toxicity. |
| Topical Antifungal Agents-Prototype | Clotrimazole |
| Clotrimazole | Works to alter cell permeability. Indicated for only local tx of mycoses. Adverse: Irritation, burning, rash and swelling. When taken as a suppository or troche: N/V, hepatic dysfunction, urinary frequency and changes in sexual activity. |
| Why is Clotrimazole only used topically? | Too toxic to be given systemically. |