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ECC Test 3 Antifung

QuestionAnswer
Mycosis Infection from a fungus
Difference between fungus and bacteria Protective layers of fungal cell make organism resistan to antibiotics
Most susceptible to fungal infections Immunosuppressant and elderly pts
Topical Antifungal Infections Tinea Infections (Ring Worm), Tinea Pedis(Athletes Foot), Tinea Cruris(Jock itch) and Candida (Yeast infection)
Amphotericin B Tx of progressive, potentially fatal fungal infections. Very long half life (24hours to 15 days). Do not use if lactating or have kidney disease. CAN be given to pregnant women cautiously. Adverse: R/t toxic effects on liver and kidneys
Systemic Antifungal Agents-Prototype Nystatin (Nilstat)
Nystatin Used for tx of intestinal Canididiasis. PO or Topical
Azoles Antifungals-Prototype Fluconazole (Diflucan)
Fluconazole PO,IV. Tx of Canidiasis, Cryptococcal meningitis. Phx agent in reducing incidence of Canididiasis in bone marrow transplant recipient. Do not use if renal dysfunction or pregnancy. Adverse: liver toxicity, GI. Inhibits CYP450 causing many D2D interactions
Ketoconazole (Nizoral) PO. Blocks activity of a steroid in fungal wall. SE: Blocks testosterone and cortisol. Do not use if pt has endocrine or fertility problems. Adverse: Hepatic Toxicity.
Topical Antifungal Agents-Prototype Clotrimazole
Clotrimazole Works to alter cell permeability. Indicated for only local tx of mycoses. Adverse: Irritation, burning, rash and swelling. When taken as a suppository or troche: N/V, hepatic dysfunction, urinary frequency and changes in sexual activity.
Why is Clotrimazole only used topically? Too toxic to be given systemically.
Created by: Hughesj29
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