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ECC Test 3 Antibio.
| Question | Answer |
|---|---|
| Bacertiostatic | Prevent growth of bacteria |
| Bactericidal | Kill bacteria |
| Broad Spectrum | Covers both Gram-Neg and Gram-Pos. Many adverse effects bc of wide range of activity effect of the drug. Given before C&S results are back. |
| Aminoglycosides-Prototype | Gentamicin |
| Gentamicin | Gram-Negative. Bactericidal. Used when penicillin is contraindicated. *Black Box Warning* |
| Gentamicin-Peak and Half Life | Peak within 1 hour. Half life 2-3 hours. |
| Gentamicin- Contraindications | Dont give to pts w/ HOH, Parkinsons or MG. Causes Nephrotoxic and Ototoxic effects. Put notice on chart if going to surgery (affects anasthesia) D2D: Diuretics, Neuromuscular blockers. |
| Carbapenems-Prototype | Ertapenem |
| Ertapenem | Broad Spectrum. Bactericidal. Tx of community acquired pneumonia, complicated GU infections, intraabdominal infections, skin infections,and acute pelvic infections. |
| Ertapenem-Peak and Half Life | Peak at end of IV infusion. Half Life 1-4 hours. |
| Ertapenem- Contraindications | Dont use on pts with seizures or meningitis. Adverse: GI(Pseudomembranous Colitis), CNS. D2D:Valproic Acid (increases seizures) |
| Cephalosporins- Prototype | Cefaclor |
| Cefaclor | Bactericidal. Similar in structure to Penicillin. Tx of Resp, Derm, urinary tract,and middle ear infections. |
| Cefaclor-Peak | Peak 30-60min |
| Cefaclor-Contraindications | Adverse:Bone marrow depression, nephrotoxicity, GI. D2D: Aminoglycosides, oral anticoagulants, ETOH for 72hrs post medication completion. (increase bleeding time) |
| Fluoroquinolones-Prototype | Ciprofloxacin |
| Ciprofloxacin | Broad Spectrum. Bactericidal. Tx of gram neg bacteria, Urinary tract, Resp, Derm, Ear, Eye, Bone and Joint infections, After Anthrax exposure, or for Typhoid Fever. |
| Ciprofloxacin- Contraindications | Do not use for children, or with pts with seizures. Adverse: CNS, GI. D2D: Antacids, Theophylline, Quinidine (monitor cardiac function if on both). |
| Sulfonamides-Prototype | Cotrimoxazole |
| Cotrimoxazole | Broad Spectrum. Inhibit folic acid synthesis. Tx of UTI, AOM, exacerbations of chronic bronchitis, and travelers diarrhea. |
| Cotrimoxazole-Contraindications | Teratoggenic! Caution with pt with hx of kindey stones and renal failure. Adverse: Nephrotic syndrome, CNS, GI, bone marrow suppression, Steven-Johnson, photophobia, hypoglycemia. D2D: Cyclosporine(Nephrotoxicity), Thiazide Diuretics (cross sensitivity). |
| Penicillins and Penicillinase-Resistant-Prototype | Amoxicillin |
| Amoxicillin | Bactericidal. Tx of strep, pharyngitis, scarlet fever, anthrax, syphillis. Peak 1 hour. Take on empty stomach. |
| Amoxicillin-Contraindications | Do not take if allergic to Cephalosporins. Adverse: GI, sore mouth, furry tongue, bone marrow suppression. D2D: Tetracycline, Aminoglycosides |
| Tetracycline | Semi-synthetic. Common soil mold. Used for acne or when penicillin is contraindicated. Take on empty stomach |
| Tetracycline-Contraindications | Do not give to children less than 8 years old. Adverse: SKELETAL, GI, Photosensivity. D2D: Penicillin G, Oral Contraceptives, Digoxin. |
| Antimycobacterial-Prototype | Isoniazid |
| Isoniazid | Tx of acid fast bacteria. Tx of TB as part of combo therapy. |
| Isoniazid-Contraindications | Do not give if pt has renal or hepatic failure. Adverse: CNS,GI,bone marrow suppression, Lupus. D2D: Rifampin, INH(causes liver toxicity) |
| Dapsone | Tx of Leprosy, pneumocystis Carnii in AIDS pts and brown recluse spider bites. |
| Ketolides-Prototype | Telithromycin |
| Telithromycin | Tx of community required pneumonia. Blocks protein synthesis. |
| Telithromycin-Contraindications | Do not give to pts with prolonged QT-interval. Adverse: Secondary to GI toxic effects. D2D: "Statins", Digoxin, Lopressor |
| Lincosamides-Prototype | Clindamycin |
| Clindamycin | Tx of chronic bone and joint infections. Adverse: GI, Bone marrow suppression, Cardiac arrest with rapid IV infusion, rash. |
| Macrolides-Prototype | Erythromycin |
| Erythromycin | Tx of Resp, Derm, Urinary Tract,and GI infections. Take without food! But with an 8oz glass of water. Adverse: GI (DIARRHEA!),liver toxicity, hearing loss. |
| Monobactam-Prototype | Aztreonam |
| Aztreonam | Tx of lower resp, derm, urinary tract, intra-abdominal and gyneo infections. Adverse: GI |