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ECC Test 3 Antibio.

QuestionAnswer
Bacertiostatic Prevent growth of bacteria
Bactericidal Kill bacteria
Broad Spectrum Covers both Gram-Neg and Gram-Pos. Many adverse effects bc of wide range of activity effect of the drug. Given before C&S results are back.
Aminoglycosides-Prototype Gentamicin
Gentamicin Gram-Negative. Bactericidal. Used when penicillin is contraindicated. *Black Box Warning*
Gentamicin-Peak and Half Life Peak within 1 hour. Half life 2-3 hours.
Gentamicin- Contraindications Dont give to pts w/ HOH, Parkinsons or MG. Causes Nephrotoxic and Ototoxic effects. Put notice on chart if going to surgery (affects anasthesia) D2D: Diuretics, Neuromuscular blockers.
Carbapenems-Prototype Ertapenem
Ertapenem Broad Spectrum. Bactericidal. Tx of community acquired pneumonia, complicated GU infections, intraabdominal infections, skin infections,and acute pelvic infections.
Ertapenem-Peak and Half Life Peak at end of IV infusion. Half Life 1-4 hours.
Ertapenem- Contraindications Dont use on pts with seizures or meningitis. Adverse: GI(Pseudomembranous Colitis), CNS. D2D:Valproic Acid (increases seizures)
Cephalosporins- Prototype Cefaclor
Cefaclor Bactericidal. Similar in structure to Penicillin. Tx of Resp, Derm, urinary tract,and middle ear infections.
Cefaclor-Peak Peak 30-60min
Cefaclor-Contraindications Adverse:Bone marrow depression, nephrotoxicity, GI. D2D: Aminoglycosides, oral anticoagulants, ETOH for 72hrs post medication completion. (increase bleeding time)
Fluoroquinolones-Prototype Ciprofloxacin
Ciprofloxacin Broad Spectrum. Bactericidal. Tx of gram neg bacteria, Urinary tract, Resp, Derm, Ear, Eye, Bone and Joint infections, After Anthrax exposure, or for Typhoid Fever.
Ciprofloxacin- Contraindications Do not use for children, or with pts with seizures. Adverse: CNS, GI. D2D: Antacids, Theophylline, Quinidine (monitor cardiac function if on both).
Sulfonamides-Prototype Cotrimoxazole
Cotrimoxazole Broad Spectrum. Inhibit folic acid synthesis. Tx of UTI, AOM, exacerbations of chronic bronchitis, and travelers diarrhea.
Cotrimoxazole-Contraindications Teratoggenic! Caution with pt with hx of kindey stones and renal failure. Adverse: Nephrotic syndrome, CNS, GI, bone marrow suppression, Steven-Johnson, photophobia, hypoglycemia. D2D: Cyclosporine(Nephrotoxicity), Thiazide Diuretics (cross sensitivity).
Penicillins and Penicillinase-Resistant-Prototype Amoxicillin
Amoxicillin Bactericidal. Tx of strep, pharyngitis, scarlet fever, anthrax, syphillis. Peak 1 hour. Take on empty stomach.
Amoxicillin-Contraindications Do not take if allergic to Cephalosporins. Adverse: GI, sore mouth, furry tongue, bone marrow suppression. D2D: Tetracycline, Aminoglycosides
Tetracycline Semi-synthetic. Common soil mold. Used for acne or when penicillin is contraindicated. Take on empty stomach
Tetracycline-Contraindications Do not give to children less than 8 years old. Adverse: SKELETAL, GI, Photosensivity. D2D: Penicillin G, Oral Contraceptives, Digoxin.
Antimycobacterial-Prototype Isoniazid
Isoniazid Tx of acid fast bacteria. Tx of TB as part of combo therapy.
Isoniazid-Contraindications Do not give if pt has renal or hepatic failure. Adverse: CNS,GI,bone marrow suppression, Lupus. D2D: Rifampin, INH(causes liver toxicity)
Dapsone Tx of Leprosy, pneumocystis Carnii in AIDS pts and brown recluse spider bites.
Ketolides-Prototype Telithromycin
Telithromycin Tx of community required pneumonia. Blocks protein synthesis.
Telithromycin-Contraindications Do not give to pts with prolonged QT-interval. Adverse: Secondary to GI toxic effects. D2D: "Statins", Digoxin, Lopressor
Lincosamides-Prototype Clindamycin
Clindamycin Tx of chronic bone and joint infections. Adverse: GI, Bone marrow suppression, Cardiac arrest with rapid IV infusion, rash.
Macrolides-Prototype Erythromycin
Erythromycin Tx of Resp, Derm, Urinary Tract,and GI infections. Take without food! But with an 8oz glass of water. Adverse: GI (DIARRHEA!),liver toxicity, hearing loss.
Monobactam-Prototype Aztreonam
Aztreonam Tx of lower resp, derm, urinary tract, intra-abdominal and gyneo infections. Adverse: GI
Created by: Hughesj29
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