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ECC Test 3-Chemo
ECC Pharm Test 3
| Question | Answer |
|---|---|
| Factors effecting response to Chemo | Tumor Cell Mass, Tumor Cell Heterogenity, Timing and Dosage, Individuals Immune System, and Placebo Effect (Psychosocial) |
| What type of status is paramount when giving Chemo? | Nutritional |
| Nadir | lowest WBC count |
| Increased doses of intermittent therapy is more benefical than continuous therapy, why? | More effective and less toxic |
| Cycle-Phase Specific Chemo Drugs | Antimetabolites (MTX, 5FU) and Vinca Alkaloids (Vincristine, Vinblastine) |
| Cycle-Phase Non-Specific Chemo Drugs | Alkylating Agents (Nit. Mustard, Cytoxan), Antibiotic Agents (DES, Tamoxifen), Immun-Modifying Agents (Interferon) |
| Which Antiemetics are used during Chemo? | Cytril, Zofran (Ondansetron-Blocks serotonin) |
| 5FU | Continuous infusion less toxic than with IV bolus |
| Vepesid | IV infuse slowly over 60 min |
| "Platin" | Think Kidneys-Check BUN and Creatine. |
| Antimetabolites | METHOTREXATE: PO,IM,IV,Intrathecal. Act specifically on DNA synthesis. Most effective in tumors with high growth fractions. Prevents conversion of folic acid. SE: Hand and Foot Syndrome. |
| Leucovor Rescue | (Vitamin-Folic Acid) allows high doses of MTX. Used for Lymphomas. |
| Vinca Alkaloids | VINCRISTINE: IV(with caution of extravastion). Blocks mitosis,M phase specific. Prevents CA cells from dividing. Most effective when cell mass is low. |
| Alkylating Agents | CYCLOPHOSPHAMIDE(CYTOXAN)(NIT.MUSTARD): IV,PO. SE:Hemorrhagic Cytitis. Interfer with DNA replication, ultimately nucleic acid function. Effective against large slow growing tumors. |
| Antibiotic Agents | DOXORUBICIN(ADRIAMYCIN):IV (w/caution). Non-cycle specific but most active in S phase. Inhibits DNA and RNA synthesis. Contain substances attained from bacteria to kill CA cells. Adverse: Red discoloration of urine, "Adriamycin Flare",Cardiotoxicity. |
| Zinecard (Dexrazoanc) | Agent used to protect heart during Adriamycin Flare. |
| Hormones and Antagonists | TAMOXIFEN: Cause tumor regression by altering hormonal environment. Block continued growth, do not kill. |
| Immune-Modifying Agents | Interferon and Neupogen (produce WBC) |
| Cisplatin (Platinol) | Nephrotoxic, Ototoxic, Neurotoxic, Ematagenic. Must keep pt hydrated 1-2L q8-12hrs prior to IV administration. |
| Ifosfamide (Ifex) | Alkylating agent. Must use with phx agent Mesna(Mesnex) for hemorrhagic cytitis. |
| Carboplatin | Similar to Cisplatin, but less toxic. |
Created by:
Hughesj29
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