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pharm c.5-5 antiretr

pharm c.5-5 antiretrovirals

QuestionAnswer
NRTIs--NUCLEOSIDE REVERSE TRANSCRIPTASE INHBITOR WORK BY DECREASEING THE AMOUNT OF VIRUS IN THE BLOOD TO SPREAD TO OTHER HEALTY CELLS
NRTIs 1ST DRUG---RETROVIR ZIDOVUDINE--(AZT) HIV
NRTIs---EMTRIVA EMTRICITABINE--ONCE DAILY NO ALCOHOL
NRTIs---HIVID ZALCITABINE---TAKE AC Q8H STORE IN AIRTIGHT CONTAINER (ORGINAL CONTAINER) 90 PER BOTTLE
NRTIs---ZIAGEN ABACAVIR---ONE IF FEW MEDICATIONS THAT PENETRATE THE CNS(VIRUS CAN HIDE IN BRAIN) AVOID ALCOHOL COMPLETELY!!--PATIENT SHOULD BE CAUTIONED TO BE ON ALERT FOR POTENTIALLY LIFE THREATING REACTIONS--50% EXPERIENCE HYPERSENSITIVITY
NNRTI--NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS ACT ON A DIFFERENT SITE THAN THE NRTIs BUT PERFORM THE SAME ACTION--KEEPS IT FROM REPLCATING
NNRTIs---SUSTIVA EFAVIRENZ--TAKE ONCE DAILY HS--AVOID HIGH FAT MEALS--MAY CAUSE DIZZINESS--MAY INDUCE VIVID DREAMS OR NIGHMARES
NNRTIs--VARAMUNE NEVIRAPINE--EFFECT LIVER--MONITOR LIVER--DECREASES EFFECTIVENESS OF ORAL CONTRACEPTIVES----RIFAMPIN DECREASE ITS EFFECTIVENESS IN HIV PATIENTS WITH TB
NNRTIs--RESCRIPTOR DELAVIRDINE--DO NOT TAKE WITH ANTIACIDS
PROTEASE INHIBITORS INHIBIT THE REPLICATION OF THE HIV VIRUS. IT HAS CLASSIC SIDE EFFECTS OF REDISTRIBUTION OF BODY FAT CHARACTERIZED BY HUMPED BACK,(BUFFOLO HUMP) FACIAL WASTING AWAY, BREAST ENLARGEMENT, DEFICIENCY OF COAGULATION (DON'T CLOT VERY WELL)
PROTEASE INHIBITORS--CRISIVAN INDINAVIR--DO NOT TAKE ST JOHNS WART, GRAPEFRUIT JUICE,HIGH FAT MEALS.--STORE IN ORGINAL CONTAINER--DRINK A LEAST 48 OUNCES OF WATER DAILY
PROTEASE INHIBITORS(COMBOS)--FORTOVASE, INVIRASE SAQUINAVIR--AVOID SUN EXPOSURE
PROTEASE INHIBITORS ---NORVIR GIVEN WITH INVIRASE RITONAVIR--TAKE W/FOOD,MAY ALTER TASTE, STORE ALL FORMS IN FRIDGE
PROTEASE INHIBITORS--REYATAZ ATAZANAVIR--PATIENT WILL TURN A LITTLE YELLOW
PROTEASE INHIBITORS--APTIVUS - TO BE TAKEN WITH NORVIR TIPRANAVIR--STORED IN FRIDGE, BLACK BOX WARNING FOR INTRACRANIAL HEMORRHAGES
PROTEASE INHIBITORS--PREZISTA DARUNAVIR--GIVEN ACCELERATED APPROVAL FOR PATIENT W/RESISTANT STRAINS OF HIV--TAKE W/ FOOD
PROTEASE INHIBITORS(TWO NEW ONES)1ST--AGENERASE AMPRENAVIR--CONTAINS HIGH DOSE OF VITIMIN E TO INCREASE ABSORPTION, CONTRAINDICATED IN PATIENT W/SULFA ALLERGIES, NUMBNESS AROUND MOUTH, NAUSEA
PROTEASE INHIBITORS--2ND--LEXIVA FOSAMPRENAVIR--BETTER TOLERATED THA AGENERASE
FUSION INHIBITORS--ONLY INJECTABLE PREVENT THE AIDS VIRUS FROM ENTERING THE IMMUNE CELLS(BIG CHANGE FROM TYPICAL TREATMENT OF HIV, GIVEN TO PATIENTS RESISTANT TO OLDER DRUGS
FUSION INHIBITORS--FUZEON ENFUVIRTIDE--GIVEN SUBCUTANEOUSLY
CHEMOKINE CORECEPTORS--LAST MADE--SELZENTRY MARAVIROC---PREVENTS VIRUS FROM ATTACHING TO IMMUNE CELLS, APPROVED FOR NEW STRAIN OF HIV(R5)--SIDE EFFECT- COUGH
INTEGRASE INHIBITORS INHIBITS THE VIRUS FROM PRODUCING INTEGRASE WHICH IS NEEDED TO REPLICATE
INTEGRASE INHIBITORS---ISENTRESS RALTEGRAVIR--REDUCES VIRAL LOAD AND INCREASE WBC COUNT,--RECEIVED PRIORITY REVIEW FROM FDA AND SHOULD BE USED IN COMBINATION W/OTHER ANTIRETROVIRALS
ANTIRETROVIRALS INTERACTIONS--SHOULD BE AVOIDED(1) VIDEX WITH HIVID
ANTIRETROVIRALS INTERACTIONS--(2) RETROVIR WITH ZERIT
ANTIRETROVIRALS INTERACTIONS--(3) EPIVIR WITH HIVID
ANTIRETROVIRALS INTERACTIONS--(4) ZERIT WITH HIVID
COMBO DRUGS---COMBIVIR ZIDOVUDINE/LAMIVUDINE---NO CHILD UNDER 12
COMBO DRUGS---TRIZIVIR ZIDOVUDINE/LAMIVUDINE/ABACAVIR--(THREE DRUGS)--D/C IF FLU LIKE SYMTOMS ARISE
COMBO DRUGS---ATRIPLA EFAVIRENZ,EMTRICITABINE,TENAFOVIR(3DRUGS)--BLACK BOX--FOR LACTIC ACIDOSIS--DISPENSE IN ORGINAL UNOPENED CONTAINER--CONTRAINDICATED IN 1ST TRIMESTER PREGNANCY
COMBO DRUGS--KALETRA LOPINAVIR/RITONAVIR--N/V/D/PANCREATISIS--CONTAINS ALCOHOL--
COMBO DRUGS---TRUVADA EMTRICITABINE/TENOFOVIR--RECOMMENDED FOR POST EXPOSURE PROPHYLAXIS(P.E.P.)80% WITHIN FIRST 2 HOURS
COMBO DRUGS--EPZICOM ABACAVIR/LAMIVUDINE---DISPENSE WITH WARNING CARD-IF PATIENT HAS TWO OR MORE OF FOLLOWING SYMTOMS: FEVER, RASH, N/V/D, FATIGUE, SOB, COUGH, SORE THROAT, THEN D/C
EXPOSURE TO HIV---POST-EXPOSURE PROPHYLAXIS PEP---BEGIN THERAPY WITH IN 2 HR, DECREASE RISK OF INFECTION BY 80%---RETROVIR+EPIVIR+(CIXIVANOR VIRACEPT)---[BEFORE TRUVADA WAS MADE]
Created by: jddmmin7