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CH 85

Tetracycline

QuestionAnswer
What are the 4 members of the tetracycline family available for systemic therapy? Tetracycline, Demeclocycline, Doxycycline, Minocycline
Administration route of Tetracycline Oral (on an empty stomach), IV (high doses associated with liver damage, IM (rare and painful)
mechanism of action of Tetracycline inhibits protein synthesis (inhibits the binding of tRNA to mRNA)
tetracycline: broad/narrow spectrum? broad
adverse effects of tetracycline administered orally: GI irritation (n/v/d/epigastric burning/cramps)
Adverse effects of tetracycline: discoloration of teeth and bones, suppression of long bone growth in premature infants, suprainfection, hepatotoxicity, renal toxicity, photosensitivity, liver dysfunction (high doses)
what is a monocycline-specific adverse effect? vestibular toxicity (dizziness, light-headedness, unsteadiness)
is long bone growth suppression in premature infants related to tetracycline reversible? yes upon DC
who should NOT receive tetracycline? pregnant women/children because of staining teeth of child/newborn
Created by: 1398660434
Popular Pharmacology sets

 

 



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