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CH 87

Sulfonamides and Trimethoprim

QuestionAnswer
Bactrum is a combo of what? Sulfonamides and Trimethoprim
Sulfonamides: Broad or narrow spectrum? broad
What is the mechanism of Sulfonamides/Trimethoprim inhibit the synthesis of folic acid which is required for DNA/RNA synthesis.
Sulfonamides: cidal/static static
what are Sulfonamides used one? UTI and Ulcerative colitis
T/F: Bactrum is used for community acquired MRSA True
administration of Sulfonamides/Trimethoprim oral
Bactrum: pregnancy no during pregnancy, it crosses the placenta
side effects of Bactrum Hypersensitivity: Steven Johnson's Rxn. Hemolytic Anemia, Leukemia, Thrombocytopenia, Photosensitivity, Kernicterus, Renal Damage from crystalluria, n/v/d, headaches, depression, hallucinations, hyperkalemia
If a rash occurs in a pt taking Bactrum, what do you do? DC immediately -> can develop steven johnson's rxn
what labs&s/s do you look at when your pt is on Bactrum? CBC (hemolytic anemia, leukopenia, thrombocytopenai, SOB on exertion, frequent infections (for the same anemia reasons)
what is the contraindication for Bactrum? sulfa allergy
What are the drug interactions with Bactrum? Warfarin(monitor PT/INR) and oral daibetics (hypoclycemia)
what lab values do you monitor in a pt on warfarin? PT/INR
Who would not receive Bactrum (think anemia)? Pts with a folate deficiency. this can lead to megaloblastic anemia
Created by: 1398660434
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