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Pharm Chapter47

Integrative Inflammation Pharmacology: Gout

MOA colchicine inhibits microtubule formation by binding to tubulin heterodimers; inhibition of microtubule asembly interrupts cellular motility and other processes necessary for neutrophil-meidated inflammatory reaction
Clinical applications colchicine acute gout, prevention of recurrent gout attacks
Adverse effects colchicine myelosuppression, diarrhea
Concomitant administration with what increaes plasma levels of colchicine? cyclosporine, tacrolimus, verapamil
MOA indomethacin Inhibit COX and inhibit prostaglandin and thromboxane synthesis
Clinical application indomethacin gout
Adverse effects indomethacin bleeding, salt and water retention, renal insufficiency
Clinical applications of prednisone, methylprednisone acute polyarticular gout, or gout assoc. with renal insufficiency
MOA allopurinol, oxypurinol Inhibit xanthine oxidase, decreases uric acid synthesis
Clinical applications allopurinol, oxypurinol Prevention of recurrent gout attacks
Adverse effects of allopurinol and oxypurinol agranulocytosis, hepatic necrosis, Stevens-Johnson syndrome, pruritus, rash
Allopurinol and oxypurinol increase levels of what? azathioprine, 6-MP
MOA sulfinpyrazone, probenecid inhibit renal tubule basolateral anion exchanger, leading to increased excretion of uric acid
Clinical applications sulfinpyrazone, probenecid Prevention or recurrent gout attacks, sulfinpyrazone- antiplatelet effects, probenecid- treats chronic HTN in patients with gout
Adverse effects sulfinpyrazone, probenecid leukopenia, thrombocytopenia, probenecid- aplastic anemia
MOA losartan Angiotensin II receptor antagonist with a modest uricosuric effect
Clinical applications losartan HTN, Prevention of recurrent gout attacks
MOA rasburicase Recombinant form of Aspergillus uricase that converts sparingly soluble urate to the more soluble allantoin
Clinical applications rasburicase tumor lysis syndrome
Adverse effects rasburicase rash
Created by: 7958184



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