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Pharm Chapter47
Integrative Inflammation Pharmacology: Gout
Question | Answer |
---|---|
MOA colchicine | inhibits microtubule formation by binding to tubulin heterodimers; inhibition of microtubule asembly interrupts cellular motility and other processes necessary for neutrophil-meidated inflammatory reaction |
Clinical applications colchicine | acute gout, prevention of recurrent gout attacks |
Adverse effects colchicine | myelosuppression, diarrhea |
Concomitant administration with what increaes plasma levels of colchicine? | cyclosporine, tacrolimus, verapamil |
MOA indomethacin | Inhibit COX and inhibit prostaglandin and thromboxane synthesis |
Clinical application indomethacin | gout |
Adverse effects indomethacin | bleeding, salt and water retention, renal insufficiency |
Clinical applications of prednisone, methylprednisone | acute polyarticular gout, or gout assoc. with renal insufficiency |
MOA allopurinol, oxypurinol | Inhibit xanthine oxidase, decreases uric acid synthesis |
Clinical applications allopurinol, oxypurinol | Prevention of recurrent gout attacks |
Adverse effects of allopurinol and oxypurinol | agranulocytosis, hepatic necrosis, Stevens-Johnson syndrome, pruritus, rash |
Allopurinol and oxypurinol increase levels of what? | azathioprine, 6-MP |
MOA sulfinpyrazone, probenecid | inhibit renal tubule basolateral anion exchanger, leading to increased excretion of uric acid |
Clinical applications sulfinpyrazone, probenecid | Prevention or recurrent gout attacks, sulfinpyrazone- antiplatelet effects, probenecid- treats chronic HTN in patients with gout |
Adverse effects sulfinpyrazone, probenecid | leukopenia, thrombocytopenia, probenecid- aplastic anemia |
MOA losartan | Angiotensin II receptor antagonist with a modest uricosuric effect |
Clinical applications losartan | HTN, Prevention of recurrent gout attacks |
MOA rasburicase | Recombinant form of Aspergillus uricase that converts sparingly soluble urate to the more soluble allantoin |
Clinical applications rasburicase | tumor lysis syndrome |
Adverse effects rasburicase | rash |