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Pharm Chapter17

Drug Addiction

MOA disulfiram Aldehyde dehydrogenase inhibitor
Clinical applications disulfiram Alcoholism
Coadministration of what with disulfiram can result in adverse CNS effects? Isoniazid
Facial flushing, headache, nausea, vomiting, weakness, orthostatic hypotension, respiratory difficulty? Acetaldehyde accumulation due to disulfiram
Opioid antagonists Naloxone, Naltrexone
MOA Naloxone, Naltrexone Block binding of opiods to mu-opioid receptor
Clinical applications naloxone Opioid overdose, Rapid reversal of opioid toxicity
Clinical applications naltrexone Opioid dependence, Alcohol dependence
Long Lasting Opiod Agonist? Methadone
MOA methadone Binds and activated mu-opioid receptor
Clinical applications methadone Opioid detoxification, Severe pain
Coadministration with what may decrease serum methadone concentration and lead to methadone withdrawal symptoms? Phenytoin
Opioid partial agonist? Buprenorphine
MOA Buprenorphine Partial mu-opioid receptor agonist, and kappa-opioid receptor antagonist
Clinical applications buprenorphine Opioid dependence, Moderate to severe pain
Sublingual preparation of buprenorphine? Suboxone, contains naloxone, to block effects of buprenorphine if parenterally administered
Gaba-ergic agonist? Acamprosate
MOA acamprosate? Stimulates inhibitory GABAergic neurotransmission in the brain and antagonizes the effects of glutamate.
Clinical application acamprosate Maintenance of abstinence in alcoholism
Created by: 7958184