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Immunologic Agents

LippinCott Williams and Wilkins Chapter 50

QuestionAnswer
Active and Passive Immunity Use of agents that stimulate antibody formation Injection of ready-made antibodies
Two types of Active Immunity Naturally active Artificially active
Natural Active Immunity person is exposed to disease, experiences disease, body manufactures antibodies to provide future immunity
Artificially Active Immunity Person given killed or weakened antigen, periodic booster is required to keep antibody level circulating
Booster injection additional dose of vaccine to boost production of antibodies to level/maintain desired immunity
Immunologic Agents Utilize body's natural defenses by stimulating the immune response to create body protection from specific disease within
Passive Immunity A supply of ready made antibodies ready to fight against the disease.
Actions and Uses: Vaccines Contains attenuated(weakened) or killed antigens that are developed to created immunity to certain diseases.
Actions and Uses: Toxin Poisonous substance produced by some bacteria that causes tetanus which is capable of stimulating the body to produce antitoxins.
Actions and Uses: Vaccines and Toxoids routine immunizations of infants and children immunization of adults against tetanus adults at high right for certain diseases children or adults at risk for exposure to a particular disease immunization of prepubescence girls against rubella
Actions and Uses: Immunoglobins Solutions obtained from human or animal blood containing antibodies formed by body to specific antigens.
Actions and Uses: Antivenins Used for passive, transient protection from toxic effects of bites by spiders and snakes.
Adverse Reactions: Vaccines and Toxoids chills fever muscular aches and pains rash lethargy pain and tenderness at the injection site hypersensitivity reaction
Adverse Reactions: Immunoglobins Urticaria Angioedema Erythema Malaise Nausea Diarrhea
Adverse Reactions: Antivenins Hypersensitivity Apprehension Flushing Itching Urticaria Edema of the face, tongue, throat Dyspena Cyanosis
Contraindications and Precautions: Vaccines and Toxoids patients with acute febrile illnesses, leukemia, lymphoma, immunosuppressive illness, or drug therapy, non localized cancer
Contraindications and Precautions: Immunologic agents used with extreme caution in individuals with history of allergies
Contraindications and Precautions: Immunoglobins history of allergic reactions after administration of human immunoglobulin preparations isolated immunoglobulin A deficiency
Contraindications and Precautions: Antivenins patients with hypersensitivity to horse serum or any other component of serum
Interactions: Vaccines and Toxoids Corticosteroids; Antineoplastic drugs; Radiation therapy: Depress immune system Salicylates administered with varicella vaccination: Risk for Reye’s syndrome develops
Interactions: Immunoglobins and Antivenins Antibodies in immune globulin preparations interfere with immune response to live virus vaccines, particularly measles, others, such as mumps and rubella
Nursing Process: Assessment Preadministration assessment: Obtain allergy history, before administration of any vaccine. Tell MD if patient is known to have allergies of any kind. Determine whether patient has any conditions that contraindicate administration of agent
Nursing Process: Assessment On going assessment: Ask patient to stay in clinic or office for observation after injection to observe for signs of hypersensitivity Keep emergency resuscitation equip. readily available in case of severe hypersensitivity reaction.
Nursing Process: Planning Expected outcome Optimal response to immunologic agent: Support of patient needs related to the management of common adverse drug effects Understanding of and compliance with prescribed immunization schedule
Nursing Process: Implementation Promoting and optimal response to therapy Read directions enclosed with vaccine Document following information in patient’s chart or form: Date of vaccination; Route and site, vaccine type, manufacturer Lot number and expiration date Name, address, title of individual administering vacci
Nursing Process: Implementation Monitoring and managing patient needs: Pain: Acute Increase fluids in diet, allow for adequate rest Keep atmosphere quiet and nonstimulating Treat local irritation at injection site with warm or cool compresses, depending on patient’s preference
Nursing Process: Implementation Monitoring and managing patient needs: Ensuring effective therapeutic regimen management Encourage parents to have their infants and young children receive immunizations Provide parent with copy of the record of immunizations
Nursing Process: Implementation Educating the patient and family: Discuss risks of contracting vaccine-preventable diseases, benefits of immunization Instruct parents to bring immunization records to all visits Provide date for return for next vaccination Discuss adverse reactions, methods to combat these reactions
Nursing Process: Evaluation Therapeutic effect is achieved Disease does not present itself Adverse drug reactions: Managed successfully Patient or parents/guardians comply with the immunization schedule Patient and family express understanding of need for immunizations
Created by: molliejae
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