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Pharm Ch 28

Reproduction

QuestionAnswer
GnRH Agonists (continuous administration suppresses hypothalamic-pituitary-gonadal axis) Leuprolide, Goserelin, Nafarelin
GnRH antagonists Cetrorelix, Ganirelix
5α-Reductase Inhibitor (blocks conversion of testosterone to the more potent DHT) Finasteride
Aromatase Inhibitors (blocks conversion of testosterone to estrogen) Exemestane, Formestane, Anastrozole, Letrozole
Only SERM approved for treatment and prevention of breast cancer; it is an estrogen receptor antagonist in breast tissue, but a partial agonist in the endometrium and bone Tamoxifen
SERM antagonist activity in breast/endometrial tissue, agonist in bone Raloxifene
SERM used to induce ovulation; acts as an estrogen receptor antagonist in the hypothalamus/anterior pituitary, and as a partial agonist in the ovaries Clomiphene
Androgen Receptor Antagonist approved only for the treatment of metastatic prostate cancer, but drug is also used therapeutically in the treatment of BPH Flutamide
Androgen Receptor Antagonist originally approved as aldosterone receptor antagonist, also has significant antagonist activity at the androgen receptor Spironolactone
Androgen Receptor Antagonist has both progestational and anti-androgen effects and used as a progestin in some estrogen-progestin contraceptives Drospirenone
Progesterone Receptor Antagonist used to induce 1st trimester abortion Mifepristone – (RU-486)
Progesterone Receptor Antagonist inhibits the growth of tissues derived from the endometrium (may be effective in treatment of endometriosis and uterine leiomyomata (fibroids)) Asoprisnil
Progestins with the highest androgenic activity Norgestrel and levonorgestrel
Progestin that also has anti-androgenic activity Drospirenone
Combination Estrogen-Progestin Contraception: vaginal ring contains... ethinyl estradiol and etonogestral
Combination Estrogen-Progestin Contraception: transdermal patch contains ethinyl estradiol and norelgestromin
The 2 progestin-only pills (“mini-pill”) norgestrel and norethindrone
Progestin-Only Contraception given parentally every 3 months Medroxyprogesterone acetate
A silastic implant effective for 3 years that is typically inserted to dorsal side of arm releases what progestin-only drug? etonogestrel
Emergency (Morning-After) Contraception Levonorgestrel
What combinations have been demonstrated to be effective, reversible male contraceptives? testosterone enanthate (IV) + levonorgestrel (PO); testosterone undecanoate (IV) + medroxyprogesterone acetate (IM)
Androgens used for hormone replacement therapy? testosterone enanthate and testosterone cypionate (or transdermal testosterone patches)
Created by: fmuralid
Popular Pharmacology sets

 

 



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