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UTI pharm
Pharm II
| Question | Answer |
|---|---|
| MC bacterial infection | UTI’s |
| What are the gender differences in UTIs | MC in male neonates, 30 more common in 20-40yo |
| RF’s | Know em |
| Upper UTI | pyelonephritis |
| Complicated UTI | abnl anatomy of UTI, >65, preggo, DM, immunospuression, male |
| Recurrent UTI | >3UTI/year, with asymptomatic period bw caused by relapse or reinfection |
| Reinfection | caused by a new organism |
| Development of repeated infections caused by same initial organism | relapse |
| What is asymptomatic bacteriuria | bacteruria >100,000/ml urine in absence of sxs (common >65yo) |
| Lower UTI CP | Dysuria, frequency, urgency… Low back/abd pain or heaviness, suprapubic tenderness |
| Upper UTI sxs | fever, rigors, HA, N/V, malaise, localized flank pain, CVAT, abd pain, sxs of lower UTI |
| What is a diagnostic bacteria finding in men and women | F: >100,000 M: >100 |
| What is frequently present but not diagnostic of UTI | hematuria |
| MC pathogen in UTI | E. coli |
| Who do we culture for UTI | complicated cystitis, preggos, cystitis w/ clinical failure, pyelo |
| Tx goals for UTIs | Prevent or tx systemic consequences of infection, eradicate the causative organism, prevent infection recurrence |
| What is special about male UTIs | rare under 60, usually d/t underlying UT abnl, |
| RF’s in young men for UTIs | uncircumcised, sexual partner w/ uropathogenic vaginal colonization, sex w/ men |
| What happens with failure of short course of AUS | culture and Rx 2 weeks |
| What is less effective for tx for E.coli | Fosfomycin less than Bactrim or FQs |
| Duration for uncomplicated, pregnant, STD concurrency of tx | U: 3 days, P: 7 days S: 7 days |
| What do we need to check with risk for STD | pelvic exam for other STIs |
| What is kernicterius and what is it associated with | knocks off bilirubin, ↑ free bili, too much in CNS in pregnancy can cause permenant neuro sxs |
| MC bacteria in pregnancy | E. coli S. saprophyticus |
| MC bacteria in STD | C. trachomatis |
| How do we tx postmenopausal women | as an uncomplicated UTI |
| What are urologic factors that contribute to postmenopausal women | cystocele, urine incontinence, ↑ residual vol (>50ml) |
| What is the only effective drug for sxs | Phenazophyridne (pyridium) urinary analgesic |
| Why do we take caution in prescibin pyridium | can mask sxs of UTI not responding to abx, only recommended 2 days post infection |
| AE’s of pyridium | HA, dizzy, stomach cramps, urine color orange or red, stain clothing |
| When and why do we not prescribe pyridium | in pts w/ CrCl <50ml/min, can interfere w/ dx tests |
| Dose of pyridium | 100-200mg tid pc x 2 days |
| When is cranberry juice effective | MIGHT have effect on prevention of UTI none for tx, should take capsules d/t ↑ sugar with all the juice. |
| How does cranberry juice attribute to tx | it has some abx therapy |
| What are 3 UTI prevention options | hygiene: void post intercourse, proper wiping, Lactobacillus probiotics: and topical estrogen in postmenopausal women |
| What does lactobacillus probiotics do | help prevent UTIs in females by ↑ vaginal pH and ↓ E. coli colonization |
| MOA of topical estrogens | post 1 m replacement ↑ lactobacillus, same as above |
Created by:
becker15
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