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1.14 capsules
Capsules
| Question | Answer |
|---|---|
| Which is more expensive to make: tablets or capsules? | Capsules |
| Most popular substance to make capsules? | Gelatin |
| Cap and Body | Capsule Components |
| Type A Gelatin is made from | Pork skin via Acid Hydrolysis |
| Type B Gelatin is made from | Bovine bones via Alkaline hydrolysis |
| Gelling Temperature | 30-35 degrees C |
| What is used as alternative to GELATIN when making capsules? | HPMC |
| Why is HPMC used as an alternative to GELATIN? | Not affected as much by moisture content; mechanical strength is retained |
| Bloom Strength | Indicates the firmness of the gel |
| Ideal Bloom Strength range | 150-280 |
| Viscosity is used to... | Control the Thickness of the gel |
| Ideal Viscosity range | 30-60 millipoise |
| Iron Oxide | Capsule colorant |
| Titanium Dioxide | Capsule opaquant |
| Parabens (Methyl and Propyl) | Capsule preservative |
| What capsule size is most common? | Size One |
| The LOWER the number, the ______ the capsule. | Bigger |
| Normal equilibrium capsule mosture content | 13-16% *<13 is too brittle, >16 is too soft |
| Ideal storage conditions for HPMC capsules | 3-7% *can be dried to 1% and still maintain mechanical strength |
| Glycerin, Propylene Glycol, or Sorbitol(Polyhydric Alcohol) | Plasticizing Agent used for SGC |
| _____ capsule is better for stability and bioavailability. | Softgel |
| What is the residual shell moisture of SGCs? | 6-10% |
| _____, _____ weight ______ soluble, ________ organic compounds should not be used in SGC | Water; low molecular, water; volatile |
| Rate of Penetration in water depends on what? | Thickness of the shell wall |
| Does Gelatin or HPMC release drug faster? | Gelatin |
| The RATE OF GELATIN SOLUBILITY is dependent on what? | Temperature *Below 35C, solubility decreases. Below 30C, insoluble |
| HPMC Solubility slowly and uniformly happens between ____ and ____. | 10-55C |
| Most frequently used method for CAPSULE DISSOLUTION TEST | Rotating Paddle Method |
| Water droplets are observed inside gelatin capsules after _______ seconds | 30-40 |
| Capsules swell up when placed in ______ | Water |
| Which is smaller, 000 capsule or 5 capsule? | 5 *like earring gauges |
| Lozenge | Disc shaped, medicinal, slow dissolving, localized medication |
| Troche | Compressed Lozenge |
| Soft Lozenge | PEG based lozenge |
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