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1.14 Tablet Coating

Tablet coating

QuestionAnswer
Solvent System/Vehicle Non-Aqueous & Aqueous Film Coating
Film Former Non-Aqueous & Aqueous Film Coating
Alloying Substance Non-Aqueous Film Coating
Plasticizer Non-Aqueous & Aqueous Film Coating
Surfactant Non-Aqueous Film Coating
Opaquants and Colorants Non-Aqueous & Aqueous Film Coating
Sweetner, flavors, and aromas Non-Aqueous Film Coating
Glossant Non-Aqueous Film Coating
Alcohol-Acetone Mix Solvent System (Non-Aqueous) *Permits rapid evaporation, speedy recovery
Hydroxy Propyl Methyl Cellulose (HPMC) Film Former *Produce smooth, thin, reproducible and versatile films
PEG Alloying Substance *Provide water solubility/permeability to ensure penetration
Glycerin Plasticizer
Propylene Glycol Plasticizer
Castor Oil Plasticizer
Polyoxyethylene sorbitan derivatives (Spans and Tweens) Surfactant
Titanium Dioxide Opaquant (Non-Aqueous)
FD&C Dyes Colorants
Beeswax Glossant
Carnauba Wax or Beeswax Used for Polishing step (Step 6)
Iron Oxide Opaquant (Aqueous)
AQUACOAT Solvent System (Aqueous) *Better than regular water-based solvent (alternative)
Picking Appearance of small and large fragments from surface of the tablet
Orange Peel Effect Roughness of tablet surface; spray drops failure to atomize
Mottling Uneven distribution of color
Bridging Filling in of score line; caused by internal stress breaking adhesive bonds between coats
Erosion Disfiguration of tablet when exposed to coating for a long time
What's CAP (Cellulose Acetate Phthalate) used for? Enteric Coating of a tablet
PVAP (polyvinylacetatephthalate) is used for ________ Enteric Coating of a tablet
Use ______ for enteric coating to make tablet dissolve in DUODENUM PVAP *More stable in gastric fluid and moisture
Use _______ coating for moisture sensitive materials Compression *Anhydrous Process
Created by: 23704589
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