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1.14 oral tablets
oral tablet stuff
| Question | Answer |
|---|---|
| Mannitol | Diluent, Flavoring/Sweetning Agent |
| Lactose | Diluent, Flavoring/Sweetning Agent |
| Sucrose | Diluent, Flavoring/Sweetning Agent |
| Calcium Sulfate | Diluent |
| Microcrystalline Cellulose | Diluent, Binder |
| Dicalcium Phosphate + Lactose | Diluent |
| Citric Acid | Effervescent Salt |
| Tartaric Acid | Effervescent Salt |
| Sodium Bicarbonate | Effervescent Salt |
| Starch Paste | Binder |
| Gelatin Solution | Binder |
| Glucose Solution | Binder |
| Methylcellulose | Binder |
| Ethylcellulose | Binder *Insoluble in water but binds in alcohol; for moisture sensitive drugs |
| Ideal Binder amount | 5-15% |
| Talc | Lubricant, Glidant |
| Magnesium Stearate | Lubricant |
| Calcium Stearate | Lubricant |
| Sodium Lauryl Sulfate (SLS) | Lubricant, Surfactant |
| Ideal Lubricant/Glidant amount | <1%; poor selection/XSS can cause "waterproofing" (Lubricant) |
| Glidants do what? | Improve FLOW of powder mix; added ONLY in dry state prior to compression |
| Colloidal Silicon Dioxide | Glidant (Most Common) |
| Starches | Disintegrant (in powder form), Binder (in liquid form) |
| Cellulose | Disintegrants |
| Algins | Disintegrants |
| Gums | Disintegrants |
| Cross-Linked Polymers | Disintegrants |
| Corn Starch Powder | Disintegrants (Most Common) |
| Ideal Starch amount | 5-15% |
| Croscarmelose | Super Disintegrant |
| Crospovidone | Super Disintegrant |
| Sodium Starch Glycolate (Explotab) | Super Disintegrant |
| Ideal Super Disintegrant amount | 2-4% |
| Aspartame (Searle) | Sweetening/Flavoring Agent |
| FD&C Red No. 3 | Coloring Agent |
| FD&C Yellow No. 5 | Coloring Agent |
| FD&C Blue No. 1 | Coloring Agent |
| Appearance, weight, uniformity are assessed in what stage? | Quality Assurance |
| Hardness of ORAL COMPRESSED TABLETS | 4-8 kg |
| Hardness of CHEWABLE TABLETS | 3 kg |
| Friability | Tablet's ability to withstand S&H |
| Acceptable Friability Damage Amount | < or = to 1% |
| Weight variation standard minimum amount | >50 mg AND drug represents more than 50% of weight |
| Content uniformity test standard | < 50 mg *drugs that weigh less than 50 mg must go through this test INSTEAD of the weight test |
| All USP tablets must pass a ________ test | Disintegration *in vitro test |
| The ________ test shows indication of bioavailability | Dissolution |
| All oral tablets must pass a ________ test | Dissolution |
| Preferred over PADDLE for enteric coated or beads | Basket Method |
| Preferred Default Apparatus | Paddle Method |
| Preferred for LOW SOLUBILITY cmpds when [SURFACTANT] is XSSive | Reciprocating Cylinder |
| Preferred in enteric coated, low solubility, req'd media switchovers | Flow-Through |
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