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Pharm_Kee42_Cardiac
Pharm: Kee Ch42: Cardiac drugs definitions
Question | Answer |
---|---|
Congestive Heart Failure | Heart failure or cardiac failure |
Heart failure | Heart weakens & enlarges, loses ability to pump blood thru heart & into systemic circulation |
Cardiac glycosides | Naturally occuring, found in plants |
Digitalis glycosides | Group of drugs that inhibit sodium-potassium pump => result in increase of intracellurlar Na => influx of Ca => cardiac muscle fibers contract more efficiently |
Positive inotropic action | Increases stroke volume |
Negative chronotropic action | Decreases HR |
Negative dromotropic action | Decreases conduction of heart cells |
A-fib | Cardiac dysrhythmia w/ rapid uncoordinated contractions of atrial myocardium |
Atrial flutter | Cardiac dysrhythmia w/ rapid contractions of 200-300bpm |
Therapeutic serum level for digoxin | 0.5-2ng/ml |
Bradycardia | HR less than 60bpm |
Hypokalemia | Low serum potassium level; normal range from 3.5-5.5 |
Antianginal drugs | Treat angina pectoris |
Angina pectoris | Acute cardiac pain due to inadequate blood flow to myocardium due to plaque occlusions w/in or spasms of coronary arteries |
Nitrates | Developed in 1840s, 1st agents used to relieve angina |
Preload | Amount of blood in ventricle at end of diastole |
Afterload | Peripheral vascular resistance |
Myocardial ischemia | Lack of blood supply to heart muscle |
Beta blockers | Decrease effects of SNS by blocking action of catecholamines (epinephrine & norepinephring) => decreasing HR & BP |
Calcium channel blockers (CCB) | Treatment of stable & variant angina pectoris, certain dysrhythmias, & HTN |
Cardiac dysrhythmia (arrhythmia) | Any deviation from normal rate/pattern of heartbeat |
Tachycardia | HR too fast, greater than 100bpm |
Repolarization | Return of cell membrane potential to resting after depolarization |
Hypoxia | Lack of O2 to body tissues |
Hypercapnia | Increased CO2 in blood |
Depolarization | Myocardial contraction |
Antidysrhythmic (antiarrhythmic) drugs | Restore cardiac rhythm to normal |