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1.14 topical TTD
topical and TTD
| Question | Answer |
|---|---|
| Petrolatum, Yellow Petroleum, Petroleum Jelly (Vaseline) | Hydrocarbon Base |
| White Petroleum (White Vaseline) | Hydrocarbon Base (Decolorized Petrolatum) |
| Yellow Ointment (Simple Ointment) | Hydrocarbon Base (95% petrolatum, 5% beeswax) |
| White Ointment | Hydrocarbon Base (White wax and White Petrolatum) |
| Anhydrous Lanolin (WOOL FAT) | Absorption Base |
| Hydrophilic Petrolatum (AQUAPHOR) | Absorption Base |
| Lanolin | Absorption Base (Already w/o emulsion) |
| Cold Creams | Absorption Base (Already w/o emulsion) |
| Hydrophilic Ointment | Water Removable Bases (o/w emulsion) *3 Phases: Oil, Water, Emulsifier |
| PEG Ointment | Water Soluble Base *aka "Greaseless"; 40% PEG3350, 60% PEG400 |
| CREAM | Semisolid o/w or w/o emulsions *Less viscous, less greasy than ointment |
| Vanishing Cream | Large % of Water and Stearic Acid (or derivative |
| LOTIONS | Suspension or o/w emulsion; uniform application over large area |
| GEL | Semi-transparent, non-greasy, semisolid formulation |
| Acacia, Xanthan | Natural Gum Gels |
| Carbomers | Gelling Agent |
| MC, CMC, HPMC | Cellulose Derivative Gels |
| Poloxamers | Gelling Agent |
| PASTES | Large % of solid, VERY viscous *Form protective barrier and absorb SERIOUS secretions |
| COLLODIONS | Liquid prep. containing PYROXYLIN (cellulose nitrate) in VOLATILE SOLVENT mix *Occlusive, seals small wounds & protect skin |
| Clobetasol Prop. Cream, Oint | CLASS I (most potent) |
| Hydrocortisone Cream, Oint, Lotion | CLASS VII (least potent) |
| NO 1st pass | TTD ADVANTAGE |
| Continuous sustained release | TTD ADVANTAGE |
| Simple Administration, improved pt. compliance | TTD ADVANTAGE |
| Easy to terminate (Adv. rxn) | TTD ADVANTAGE |
| Drug Spectrum Limited | TTD DISADVANTAGE |
| Slow Absorption Rate | TTD DISADVANTAGE |
| Allergic, irritant rxns | TTD DISADVANTAGE |
| Cost | TTD DISADVANTAGE |
| Monolithic System | Backing layer, drug in POLYMER MATRIX, Adhesive Layer |
| Reservoir System | Backing, Reservoir, Adhesive, *Rate-controlling membrane |
| Matrix-diffusion system (Higuchi Release Kinetics) | Monolithic System |
| Membrane-moderated system (Fick's First Law) | Reservoir System |
| Iontophoresis | Small electrical current *Flow of electrical current may increase permeability of skin |
| Iontophoresis can deliver ________ molecules | Ionized |
| Lidosite (Lidocaine & Epinephrine) | Iontophoretic Drug Delivery System |
| Ionsys (fentanyl) | Iontophoretic Drug Delivery System |
| Sonophoresis | High voltage pulses produce transient pore *Useful for proteins and peptides |
| Microneedle Array | Microprojection drug delivery |
| Macroflux | Microneedle Array |
| Needleless Jet Injector | Delivers Medication under pressure from gas cartridge |
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