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Pharm - Ch. 90, 92

Fluoroquinolones and Antiviral Agents for Non-HIV Infections

QuestionAnswer
What is the prototype for fluoroquinolones? Ciprofloxacin
True or false: ciprofloxacin is a broad spectrum antibiotic True
What is the mechanism of action for ciprofloxacin? Inhibits bacterial DNA gyrase, hence bactericidal
ow is ciprofloxacin used? Treats UTI, respiratory, GI, bones, skin. Drug of choice for anthrax
Ciprofloxacin can be given ______ when treated at home PO
How does resistance develop? Alterations in bacterial DNA gyrase and reduced influx into cell
List the adverse effects of ciprofloxacin GI (nausea/vomiting, diarrhea, abdominal pain), CNS (dizziness/headache), potential for tendon rupture, candida of pharynx and vagina
True or false: ciprofloxacin is contraindicated in patients under 18 years of age True. Concern for tendon rupture
Foods with ____ will decrease drug absorption Cations. (Extra: what other drug has interactions with cations? ...tetracycline
A nurse is teaching a patient who has been prescribed ciprofloxacin. What is one thing she should recommend? Take drug on empty stomach to avoid poor absorption of drug
Acyclovir is used to treat ______ and _______ Herpes simplex and varicella zoster
Acyclovir is a purine _____ analog Nucleoside
Explain the mechanism of action of acyclovir Inhibits DNA polymerase and suppresses synthesis of viral DNA by inserting itself where the "G" should be in DNA strand
True or false: acyclovir is a prodrug True. Gets activated by enzymes found in virally infected cells
What are adverse effects of acyclovir? Depends on route of administration. IV = phlebitis/reversible nephrotoxicity. PO = GI/vertigo. Topical = stinging sensation
Created by: choel
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