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Mod X Pharm Charm

Mod 10 Pharm Exam 4

QuestionAnswer
Inhibits the action of histamine at the H-2 receptor site located primarily in gastric parietal cells, resulting in inhibition of gastric acid secretion. H2 blockers MOA
Cimetidine [Tagamet] is usually a very safe drug! H2 blocker/Antiulcer drugs
Confusion, agitation and hallucination CNS side effects of Antiulcer Drugs
dizziness drowsiness headaches SE of Antiulcer Drugs
inhib drug metab enzymes (CP450)in the liver Cimetidine
this drug may lead to increase blood levels in toxicity with: Warfarin Nifedipines Propranolol Quinidines Phenytoin Benzodiazepines Theophylline Lidocaine Cyclic Antidepressants Carmustine Carbamazepine E CIMETIDINE [TAGAMET]
reduce dose of this drug in the elderly and pts with renal and hepatic dysfunction Cimetidine [Tagamet]
Treats: Active Duodenal Ulcers Benign Gastric Ulcers Prophylaxis of Duodenal Ulcers Acid-Hypersecretory conditions GERD taken at hs (bedtime) Cimetidine[Tagamet]
This drug: suppresses Gastric Acid specific and irreversible inhibition of hydrogen and potassium ATPase enzyme system at the secretory surface of gastric parietal cells Site: Liver FINAL step in secretion of HYDRPCHLORIC ACID Prevents GERD Proton Pump Inhibitor
an example of [Prilosec] Omeprazole Proton Pump Inhibitor
all of these drugs have these side effects: dizziniess drowsiness fatigue headaches Antiulcer drugs
weakness Proton Pump Inhibitors SE
abdominal pain acid regurgitation flatulence Proton Pump Inhibitors SE
metabolized by CP450 and may compete with these drugs: DIAZepam PHENYtoin WARfarin (3) drugs! Proton Pump Inhib drig interactions
breast feeding mothers should not take this drug! CI of Proton Pump Inhib
Treats: GERD Duodenal Ulcers Pathological Hypersecretory conditions H. Pylori gastritis Proton Pump Inhibitor uses
SUCRALFATE [Carafate] Antiulcer Drugs
Misoprostol [CYTOTEC] Antiulcer Drugs
a complex aluminum-polysaccharide that covers the ulcer site with a viscous gel and protects it against acid, pepsin and bile salts SUCRALFATE [Carafate] MOA!
synthetic prostaglandin decreasing gastric acid secretion and increasing the production of protective mucus MISOPROSTOL [CYTOTEC] MOA!
Constipation SE of SUCRA-CARAFATE
DIARRHEA SE of CYTOTEC
this drug interferes with absorption of: Digoxin BB Antiarrythmics Fluoroquinolones SUCRA-CARAFATE drug interactions
drug interactions are with magnesium-containing antacids [CYTOTEC] Misoprostol
should be used cautiously in pt with renal failure SUCRA-CARAFATE
CI in pregnant or lactating moms. It can cause an ABORTION in the 2nd trimester and in general is a potent abortion drug [CYTOTEC] Misoprostol
Given before meals "ac" and at "hs" bedtime but NOT given within 30 min Antiulcer drugs contraindications
short-term management of duodenal ulcers prevents duodenal ulcers SUCRA-CARAFATE
used for cervical ripening when inserted vaginally [CYTOTEC] MISOPROSTOL
used in prevention of NSAID induced gastric ulcers in pt at high risk of complications from a gastric ulcers [CYTOTEC] MisoprostoL
decrease or neutralize gastric cid raises gastric pH reduce pepsin activity MOA of ANTACIDS
Aluminum or Magnesium Hydroxide Calcium Carbonate Sodium Bicarbonate Examples of Antacids
an antifoaming of defoaming drug to manage flatulence and bloating [Gas-X] [Mylicon] SIMETHICONE
an ingredient in Gaviscon tab Alginic Acid
altered gut motility Side/Adverse effects of Antacids
Constipation Aluminum and Calcium Carbonate antacid SE
Diarrhea Magnesium salt antacid SE
these drug interacts with and interferes with absorption of: Tetracyclines Fluoroquinolones Penicillamine Azole Antifungals Antacid drug interactions
they should NOT be used with enteric-coated preps like Dulcolax Antacids Contraindications
they should be seperated from administration of other drugs by at least one hour Antacid contraindications
create a local environment that favors healing rather than stimulating cell growth and tissue repair. These drugs need to be taken until the ulcer heals! Antacids
act in small and large intestine by absorbing water Laxatives {metamucil]
forming a soft, bulky mass that stimulates the normal intestinal reflexes Laxatives[Metamucil]
stir the powder well in a full glass of liquid and drink promptly Laxatives [Metamucil]
treats diarrhea [Metamucil] Psyllium
when given orally they act in the small & large intestines to draw water from the capillaries into the gut lumen SALINE LAXATIVES [MOM]
increses fluid in the intestine [MOM] Milk of Magnesia
Stimulating local stretch receptors [MOM]
some saline laxatives are mild laxatives [MOM]
Mg and Citrate are laxatives witha cathartic action that acts in a few hours [MOM] Milk of Magnesia Saline Laxatives
Action may be TOO prompt or TOO excessive with fluid electrolyte loss Interfere with the absorption of dietary nutrients Side/Adverse effects of Saline Laxatives
inhibit rythmic bowel reflexes...leads to dependency Mg salts pose risk in pt with poor renal function Side/Adverse effects ofSaline Laxatives
suppository evacuates colon in 15-60 min similar action to saline products draws water into rectum Hyperosmotic laxatives: GLYCERIN
stretches the rectum stimulates defecation used in small kids Glycerin (HYPEROSMOTIC laxatives)
GOLYTELY is NOT likely to alter systemic fluid or electrolyte balance Polyethelene glycol
induces diarrhea in 30-60 min cleanses the bowel used prior to diagnostic procedures (colonoscopy) Polyethylene glycol (Golytely)
these are the least natural laxatives! Stimulant Laxatives
these laxatives: stimulate nerve endings in the intestine increases peristaltc movement should NOT be administered for more than one week not used initially Stimulant laxatives
rupture of weakned intestine chronic use suppresses normal bowel reflexes excreted in breast milk SE/AR of stimulant laxative
watery evacuation griping or cramping [Dulcolax] Bisacodyl
CI in pregnancy has an irritating effect and may stimuoate the uterus Castor Oil
tablets are enteric coated CI: should not be given with alkaline substances like milk or antacids Dulcolax tablets
irritates the stomach and cause N&V Dulcolax Tab
reduce surface tension of stool help form mixture between fats and water hard, dry stool becomes soft [Colace] "surfactant" stool softeners
given post-op used to ease pain in pt with hemorrhoids or CVAs used in pregnancy stool softeners [Colace] "surfactant"
are NOT used with mineral oil CI in stool softeners
coats fecal mass with oily film that lubricates feces eases passage of feces through gut barrier against absorption of water from feces Lubricants (Mineral Oil)
reduce absorption of oil-soluble vitamiuns (A,D,E,K) leak pass the anal sphincter to stain clothes Lubricants (Mineral Oil)
Deposits oil in liver when aspirated can cause lipid pneumonia Pt who take the drug at hs suffer from these SE (elderly and debilitated) SE/AR of Lubricants (Mineral Oil)
causes local irritation of GI tract PO Stimulates CTZ induces vomiting in pt who have taken toxic doses of drugs Emetic Drug (Syrup ofIpecac)
this drug is not an antidote does not treat poisoned pt Syrup of IPECAC
transdermal patch prevents motion sickness prevents N&V used in pre-op and post-op pt Scopolamine (Antinauseants)
sedation anticholinergic effect add to the action of other CNS depressants Addto drugs with anticholinergic effect Dimenhydrinate [Dramamine]
block central dopamine receptors eefective against block N&V
most commonly prescribed drugs for N&V used preop and postop dopamine receptor blocker Prochloroperazine (Compazine) and Promethazine
dopamine receptor blocker IV to reduce N&V Parentereal cancer chemotherapy REGLAN
capsule principle psychoactive substance in weed highly abusable DROnabinol (marinol)
treats N&V associated with chemotherapy appetite stimulate the gut DROnabinol (marinol)
act locally to bind to noxious substances that stimulate gut Adsorbents
[kaopectate] adsorbent
pepto-bismol prevents traveler's diarrhea adsorbent
this drug has a constipating effect Opioid derivatives
Diphenoxylate with atropine [Lomotil]
Loperamide OTC Immodium AD
These drugs are: Free of pain relief no euphoria no abuse-promoting effect effect the Mu recep in the gut decr propulsive movements more time for water to be absobed from the feces Immodium AD and Lomotil
this drug treats CRAMPS and DIARRHEA treats Crohn's disease (chromic diarrhea, abdominal pain, fever, weight loss) Colitis Drugs (Anticholinergic)
preps containing 5-aminosalicylic acid have an inflammatory action treats Crohn's disease Aminosaliculic Acid
Anti-inflammatory site: Colon inhibition of prostaglandid synthesis treats crohn's [AZULfidine] Sulfasalazine
contains aminosalicylic acid neutralizes and prevents/blocks the activity of a TNF alfa anti-inflammatory treats Crohn's treats pt who have not resp to another conventional therapy [Remicade]Inflixmab
Site: Colon inhibits prostaglandidn synthesis treats ULCERATIVE COLITIS (bloody shyt) Given by enema, rectal suppository, or PO [Rowasa] Mesalamine
abdominal pain with constipation or diarrhea that is triggered by food ingestion Irritable bowel syndrome drugs
[Lontronex] and [Zelnorm] treat? IBS
Seretonin modulators treats IBS
[Lonotrex] inhibits the activation of serotonin-5 HT3 receptors (non-selective cation channel) IBS Drugs
[Zelnorm] acts as a partial agonist of 5-HT3 and 5-HT4 recep Zelnorm releases neurotransmitters increased peristalsis secretion visceral sensitivity IBS Drugs
an irreversible inhibitor of GI Lipase Decreases the amount of ingested dietary fat that is absorbed increases fatal fat excretion Alli [Xenical] Orlistat drugs that treat obesity
Created by: boomer_bevo
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