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PHM1810 Chp 8 Drugs

Pharmacology I: Chapter 8: Seizure Drugs (Entire)

QuestionAnswer
Klonopin clonazepam; benzodiazepine
Tranxene chlorazepate dipotassium; benzodazepine
Valium diazepam; benzodiazepine
Cerybyx fosphenytoin; hydantoin
Dilatin phenytoin; hydantoin
Tegretol carbemazepine; phenytoin-like drug
Felbatol felbamate; phenytoin-like drug
Lyrica pregabalin; phenytoin-like drug
Mysoline primidone; phenytoin-like drug
Gabitril tiagabine hcl; phenytoin-like drug
Topamax topirimate; phenytoin-like drug
Depaken/Depakote valproic acid; phenytoin-like drug
Zonegran zonisamide; phenytoin-like drug
Zarontin ethosuximide; succinimide
Celontin methsuximate; succinimide
Hydantoin mechanism of action desensitizing sodium channels in the CNS responsible for neuronal responsiveness, thereby preventing the spread of disruptive electrical charges in the brain that cause seizures
Hydantoin adverse effects inability to coordinate muscle activity, confusion, dizziness, insomnia, headache, gingival hyperplasia, reduction of blood cells, hepatitis , hypotension, hyperglycemia
Phenytoin-Like Agents Mechanism of Action resemble the mechanism of action of phenytoin (sodium channel desensitization)
Phenytoin-Like Agents Adverse Effects drowsiness, sedation, GI upset, prolonged bleeding, visual disturbances, muscle weakness, bone marrow suppression, rash, fatal liver toxicity, weight gain, loss of hair, abdominal pain
Succinimides Mechanism of Action delay entry of calcum into neurons, thus increasing the electrical threshold and suppressing EEG patterns associated with petit mal seizures. Otherwise not entirely understood.
Succinimides Adverse Effects ataxia, dizziness, nervousness, headache, blurred vision, vaginal bleeding, muscle weakness, behavioral changes, abnormal liver and kidney function tests
Created by: MrsAFlaherty
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