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Pharm2 Lect 2

Pharm2 Receptors & Adrenomimetics

QuestionAnswer
Parasympatheic effects on the lens M3 receptors are activated to contract the ciliary muscle, which releases tension in suspensory ligaments rounding the lens for near vision.
What side effects will be seen with a M antagonist administered for pupil dilation? Blurred vision becuase of an inability to contract the ciliary mucles.
Will an alpha1 agonist cause blurred vision? NO!!
What type of M receptors are located on the heart? M2
What type of M receptos is activated to cause lacrimation in the lacrimal glands? M3
What type of M receptor is activated in the bronchiole smooth muscle and glands? M3
What endogenous catecholamine will bind to and activate B2 receptors in the lungs? EPI
What two types of drugs could be given to open up someone's airway? 1.B2 agonists. 2.M receptor blockers (anticholenergics)
Physiological antagonists An antagonistic response generated by two different receptors
Physiological antagonists of bronchoconstriction? Pharmacological antagonist? 1.Phys: B2 agonist. 2.Pharm: M antagonists.
What receptors are sympathetic targets in the GI? 1.A1: constrict the sphincters. 2.B2: smooth muscle relaxation/slowed peristalsis.
What M receptor is responsible for parasympathetic activated gastric secretions? M3. **M3 antagonist could aid in dec secretions, but not the best method.
What receptors are sympathetic targets in the bladder 1.A1: internal sphincter contraction. 2.B2: detrusor relaxation.
What drug should be used to treat incontinence from detrusor over activity? M antagonists.
Do parasympathetics have a DIRECT effect on the BV of the heart? NO! ACh does cause vasodilation, which is a secondary method via M3 receptors on endothelial cells.
Effects of PVR via M agonist? via PNS? 1.M3 agonist: Decrease PVR. 2.PNS: no change.
Blood vessels that are innervated by the PNS? do they effect PVR? 1.Secretory glands. 2.GI glands. 3.Genital erictile tissue. **NO they wont affect PVR**
What is the main controller of PVR? SNS A1 receptors. **B2 are only influential at the liver, skeletal muscle, heart, and brain.
Where all do M2 affect in the heart? 1.SA node (Dec rate). 2.Atria (Dec force of contraction). 3.AV node (Dec conduction velocity).
Where all do B1 affect in the heart? 1.SA (Inc rate). 2.Atria (Inc contraction). 3.AV node (Ince conduction velocity). 4.Ventricles (Inc contraction)
Sympathetic activation of sweat glads? 1.A1: Palms only. 2.M3: Thermoregulatory sweat. **Both use Gq which Inc [Ca+]
What is the MOST bothersome side effect of M antagonists? DRY MOUTH
What receptors are activated during low plasma glucose in the liver? B2. Epi is released from adrenal medulla which stimulates B2 causing gluconeogenesis.
Dangerous side effect of Beta blockers on diabetics? Hypoglycemic shock. **their normal B2 response to hypoglycemia will be impaired.
Beta2 and Alpha 2 affect on Pancreas? 1.A2: Dec insulin release. 2.B2: Inc Insulin release. **Predominant effect with EPI is INHIBITION.
What adrenergic receptors regulate LONG TERM BP? B1 on granular (juxtaglomerular) cells via RAAS.
Created by: WeeG
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