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Reversal agents

QuestionAnswer
All anticholinesterase drugs exhibit their effect by inhibiting the enzyme _____________ acetylcholinesterase
T or F. The site of action can occur at the pre and post synaptic membrane. True
Which drugs inhibit the enzyme acetylcholinesterase? Pyridostigmine, Edrophonium, and Neostigmine
Where is the predominant site of action of edrophonium? Presynaptic
When there is too much cholinesterase inhibition in patients with myasthenia gravis what happens? cholinergic crisis
What synthetic cholinergic agonist is used to treat urinary retention? Bethanachol
What synthetic cholinergic agonist is used to treat wide angle glaucoma and produce miosis for intraocular surgery? carbachol
What are examples of cholinomimetic alkaloids used for topical miosis and decrease IOP? Pilocarpine, muscarine, arecholine
What anticholinergics are alkaloids of the belladonna plant and are tertiary amines? Atropine and scopalamine
What is a synthetic conoger of the Belladona alkaloid and are usually quarternanry ammonium? glycopyrrolate
M1 is found where? CNS and stomach
M2 is found where? heart and lungs
M3 is found where? CNS and airway smooth muscle
M4-5 is found where? CNS
What drug has the greatest cholinergic effect on the heart and has fast onset effects? Atropine
What drug has the least effects on the heart? scopalamine
Rank antisialogue effects from greatest to least: Scopalamine > Glycopyrrulate > Atropine
Effects on the heart from greatest to least. Atropine >= Glycopyrrulate > Scopalamine
Rank in order from greatest to least sedative effect Scopalamine> Atropine > glycopyrrulate
What anticholinergic drug is often used for aerosol administration? Ipratropium
Central Cholinergic syndrome is seen mostly with administration of what drug that crosses the BBB? Scopalamine
What is the treatment of central cholinergic syndrome? Physostigmine 15-60mg IV because it crosses the BBB
Created by: Jmw015
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