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Drugs for Migraine

Pharmacology Exam 1

QuestionAnswer
Treatments for Migraines: Headache ___, Avoiding ___, diary, triggers
Migraine Drug therapy: Abortive = A___, E___ A___, S___ (T___) + additional a___. Limit use of abortive drugs to __-__ days/week may lead to M__O__H__. Only Tx for MOH is ____ of medication. or Preventative analgesics, ergot alkaloids, SEROTONIN-receptor AGONIST (TRIPTANS) , antiemetics. 1-2 days/week, Medication Overuse Headache. Withdrawal,
Aspirin, Acetaminophen, NSAIDS: - Class - ___ should be used only in combination with other drugs. - Non-Opioid analgesics - Acetaminophen
Butorphanol Nasal ___ (preferred tx) for severe migrain that has not responded to first-line medications. - Class - Spray, Opioid analgesics
Ergotamine + dihydroergotamine (combinations): - Class - (MOA): Alters transmission of s__nergic, d__nergic, and a__-adrenergic junctions. Metabolized extensively in ___ 3A4. S__/I___ Excreted in ___ primarily. Withdrawal seen especially in ___ drug. - Ergot Alkaloids - Serotonergic, Dopaminergic, Alpha-adrenergic. Liver. Substrate/Inhibitor. Liver. Bile. Ergotamine with "ergotism" OD.
Ergot Alkaloid (Adverse Effects): N/V, D__ primarily in (__). Preg __? T__/B__. (Drug Interactions): T__, Potent 3A4 __, BLACK BOX: P__ I__. (Contraindications): C_, P_. (Monitor): C__ @ baseline, C_ risk, periodic evaluation Diarrhea (Dihydroergotamine), Category X, Tachycardia/Bradycardia, Triptans, Inhibitors, Peripheral Ischemia, CAD, PVD, Creatinine, CVD risk
Sumatriptan, Zolmitriptan, Rizatriptan, Almotriptan, Frovatriptan, Eletriptam and combination therapy with sumatriptan/naproxen (NSAID) - Class (aka ___) - (MOA): __ serotonin__. Act by _ intracra blood vessels & suppressing release of i__ neuropeptides - Serotonin Receptor Agonist (Triptans) - Selective, Agonist, Constricting, inflammatory
Triptans: Metabolized ___ Excreted in ___ and ____. E___ excreted 90% non-r___ route. hepatically. urine and feces. Eletriptan, renal
Triptans (Adverse Effects): D___, T__ and C__ symptoms, Coronary V___, Preg ___? (Drug Interactions): Other Triptans and E___ ____. M__, L__, S__/S__ and serotonin receptor a___. Potent 3A4 ___. P____ with (frovitriptan and rizatriptan) Drowsiness, Throat and Chest, Vasospasm, Preg Categ C. Ergot Alkaloids. MAOIs, Lanazolid, SSRI/SNRIs, Agonists, Inhibitors, Propranolol
Propranolol, Divalproex, Amitrityline, Botox: - Indication of these drugs? - Preferred Preventative Migraine Therapy
Preferred Drugs for Migraine Prevention: B____. T___ antidepressants, Antiepileptic drugs, E___ for menstrual migraines. Other drugs: Verapamil (__) and Candesartan (__) - Beta Blocker (Propranolol), Tricyclic Antidepressants (amitriptyline), Estrogen, (CCB), (ARB)
Created by: mnc8
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