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Pharm Unit 3

Corticosteroids

QuestionAnswer
Fludrocortisone Mineralcorticoid > glucocorticoid used as an aldosterone agonist
Hydrocortisone Replacement therapy for pts with adrenal insufficiency glucocorticoid = mineralcorticoid
Cortisone Replacement therapy for pts with adrenal insufficiency glucocorticoid = mineralcorticoid 80% of anti-inf. and Na retaining potency as hydrocortisone (needs activation step)
Hydrocortisone Anti-inflammatory
cortisone Anti-inflammatory
prednisone Anti-inflammatory glucocorticoid > mineralcorticoid most commonly prescribed oral glucocorticoid (must be converted to prednilosone in liver)
methylprednisone Anti-inflammatory no mineralcorticoid activity high glucocorticoid activity
triamcinolone Anti-inflammatory no mineralcorticoid activity high glucocorticoid activity
betamethasone Anti-inflammatory
dexamethasone Anti-inflammatory preferred glucocorticoid for cerebral edema- CNS ability
fluticasone Anti-inflammatory most commonly prescribed glucocorticoid for intranasal/inhaled use
Aminoglutethimide Glucocorticoid antagonist inhibits conversion of cholesterol to pregnelone inhibits adrenal and sex steroid synth. used in Cushing's dz give corticosteroids concomitantly to supress ACTH release
ketoconazole Glucocorticoid antagonist antifungal that interacts with cP450 and inhibits steroid synth. high doses- most effective tx for Cushing's
mifepristone Glucocorticoid antagonist antagonist of progesterone recptors, and at higher doses, glucocorticoid receptors used for inducing abortions
spironolactone mineralcorticoid antagonist K sparing diuretic, competes with aldosterone used for primary aldosteronism and hirsutism
Created by: 618366825
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